geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis


, : Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology 37(3): 220-225

Aims: To investigate the histological, ultrastructural and immunohistochemical features of the vascular lining of dermal telangiectasia, a characteristic clinical finding in scleroderma.Methods: Standard histological, electron microscopic and immunohistological techniques were used to examine dermal telangiectasias in five patients with limited scleroderma, the most common scleroderma variant in Caucasian populations.Results: The telangiectasias were dilated postcapillary venules located in the papillary and superficial reticular dermis. The vessel walls consisted of non-fenestrated endothelial cells surrounded by a variable number of pericytes and smooth muscle cells. There were no unique ultrastructural features. Thickened collagen fibres in the reticular or deep dermis were seen in all but one patient, although in variable and generally minimal quantities. Surrounding infiltrating inflammatory cells were scarce. No enhanced endothelial staining was obtained with antibodies directed against endoglin, endothelin, E-selectin and ICAM-1 suggesting a resting or inactivated state.Conclusion: The immunohistological and ultrastructural features of the lining endothelium of established telangiectasias in long-standing, limited scleroderma appear benign. It would be of interest to examine telangiectasias in the early phase of their formation. Alternatively, other explanations need to be explored in understanding the aetiopathogenesis of telangiectasia in scleroderma.

US$19.90

PMID: 16175895

DOI: 10.1080/00313020500033262


Other references

Sandman, C.A.; Wadhwa, P.D.; Chicz Demet, A.; Porto, M.; Garite, T.J., 1995: Third trimester POMC disregulation predicts use of anesthesia at vaginal delivery. In a prospective study, third trimester plasma levels of BE and ACTH were determined in 58 women who delivered vaginally. Peptide regulation was compared between subjects who used conduction anesthesia at delivery and subjects who did not. Third t...

Ross, H.L.; Simon, S.; Cleary, J., 1996: License plate confiscation for persistent alcohol impaired drivers. Minnesota cancels the registrations and confiscates the license plates of vehicles driven by repeat drinking drivers in a procedure which prior research has demonstrated to be effective in reducing subsequent recidivism. The research reported here...

Robinson, J.; Clason, T., 2002: From a pasture to a silvopasture. Small farm today 2002 19(5): 40-42

Freeland, K., 2000: Economic sanctions and embargoes. Annals of Internal Medicine 133(4): 308-308

Sady S.P.; Katch V.L.; Villanacci J.F.; Gilliam T.B., 1983: Children adult comparisons of oxygen uptake and heart rate kinetics during submaximum exercise. O2 (.ovrhdot.VO2) and heart rate (HR) kinetics for submaximum exercise were compared in prepubescent boys (mean age .+-. SD = 10.2 .+-. 1.28 yr, n = 21) and adult men (30.0 .+-. 5.64 yr, n = 21). Standard open circuit spirometric techniques were u...

Manton, I., 1934: The problem of Biscutella laevigata L. This crucifer inhabits central Europe, and is subdivided into more than a dozen "subspecies." Some of the latter are diploid (2n= 18), others tetra-ploid (2n = 36). The tetraploid races have a continuous areal including Switzerland, Tyro...

Kühnisch, J.; Heinrich-Weltzien, R.; Tabatabaie, M.; Stösser, L.; Huysmans, M.C.D.N.J.M., 2006: An in vitro comparison between two methods of electrical resistance measurement for occlusal caries detection. Because of different measurement techniques and the easier design of the CRM prototype, this in vitro study aimed to compare the diagnostic performance and reproducibility of two electrical methods (Electronic Caries Monitor III, ECM and Cariomete...

Haslam R.H.A., 1985: Predictive validity of auditory brainstem responses and visual evoked potential recording in comatose patients. Canadian Journal Of Neurological Sciences: 184

Bredikis, I.Iu.; Puodzhiukinas, A.L.; Laurushonis, K.A., 1991: Ablation of ventricular tachycardia in thoracotomy without artificial circulation. Seventeen patients were operated on for ventricular tachycardia (VT). Closed heart radical surgeries destroying the arrhythmia substrate were made without employing extracorporeal circulation. A VT episode was inducible in 16 (94%) patients for VT...

Vidonho Junior, A.F.rreira; Carrilho, B.D.A.ruda; Furukawa, L.N.oko Shinohara; Silva, A.A.ves Da; Bergamaschi, C.D.T.ledo; Campos Junior, R.R.beiro De; Heimann, J.C.audio, 2003: Blood pressure and insulin sensitivity in adult offspring are influenced by maternal salt intake during pregnancy and lactation. Objective: To evaluate salt intake during the perinatal period on IS and BP in adult Wistar rats.Methods: Female Wistar rats were fed a low (LSD: 0.15% NaCl), normal (NSD: 1.3%), high1(HSD1: 4%) or high2 (HSD2: 8%) salt diet since 8 weeks of age....