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Histopathological and ultrastructural studies on the toxic effect of prianil C-R (lithium carbonate) in mouse kidney


, : Histopathological and ultrastructural studies on the toxic effect of prianil C-R (lithium carbonate) in mouse kidney. International Journal of Biology and Biotechnology 1(4): 641-654

This study was carried out to investigate the histopathological and ultrastructural alterations in the kidney of Swiss albino mice in response to the administration of prianil C-R (lithium carbonate) at a dose level of 2.32 mg/mouse daily for 30 days (therapeutic dose) and 0.58 mg/mouse daily for 90 days (quarter the therapeutic dose). Our results demonstrated severe changes involved both glomeruli and renal tubules in mice treated with high dose of lithium.

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