+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study

, : Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. Journal of the National Cancer Institute 95(23): 1772-1783

Background: Human papillomavirus (HPV), the causal agent of cervical cancer, appears to be involved in the etiology of cancer of the oral cavity and oropharynx. To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries. Methods: We recruited 1670 case patients (1415 with cancer of the oral cavity and 255 with cancer of the oropharynx) and 1732 control subjects and obtained an interview, oral exfoliated cells, and blood from all participants and fresh biopsy specimens from case patients. HPV DNA was detected by polymerase chain reaction (PCR). Antibodies against HPV16 L1, E6, and E7 proteins in plasma were detected with enzyme-linked immunosorbent assays. Multivariable models were used for case-control and case-case comparisons. Results: HPV DNA was detected in biopsy specimens of 3.9% (95% confidence interval (CI)=2.5% to 5.3%) of 766 cancers of the oral cavity with valid PCR results and 18.3% (95% CI=12.0% to 24.7%) of 142 cancers of the oropharynx (oropharynx and tonsil combined) with valid PCR results. HPV DNA in cancer biopsy specimens was detected less frequently among tobacco smokers and paan chewers and more frequently among subjects who reported more than one sexual partner or who practiced oral sex. HPV16 DNA was found in 94.7% of HPV DNA-positive case patients. HPV DNA in exfoliated cells was not associated with cancer risk or with HPV DNA detection in biopsy specimens. Antibodies against HPV16 L1 were associated with risk for cancers of the oral cavity (odds ratio (OR)=1.5, 95% CI=1.1 to 2.1) and the oropharynx (OR=3.5, 95% CI=2.1 to 5.9). Antibodies against HPV16 E6 or E7 were also associated with risk for cancers of the oral cavity (OR=2.9, 95% CI=1.7 to 4.8) and the oropharynx (OR=9.2, 95% CI=4.8 to 17.7). Conclusions: HPV appears to play an etiologic role in many cancers of the oropharynx and possibly a small subgroup of cancers of the oral cavity. The most common HPV type in genital cancers (HPV16) was also the most common in these tumors. The mechanism of transmission of HPV to the oral cavity warrants further investigation.


PMID: 14652239

DOI: 10.1093/jnci/djg107

Other references

Anonymous, 2013: What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?. The Hippo pathway was originally identified in <I>Drosophila</I> as the signalling pathway that governs organ size. The core of the pathway harbours two protein kinases (Hippo and Warts). Hippo phosphorylates and activates Warts, which...

Friedberg, F.; Greenberg, D.M., 2011: Endocrine regulation of amino acid levels in blood and tissues. Journal of Biological Chemistry 168(2): 405-409

Olson, R.; Fort-Collins, C.; Hanson, J., 1987: A knowledge-based deduction system for curve-shape analysis. AI applications in natural resource management 1(2): 3-11

Ramos-Luengo, A.; Asensio-Merino, F., 2017: Hypnosis closed loop TCI systems in outpatient surgery. Determine the influence of general anaesthesia with closed-loop systems in the results of outpatient varicose vein surgery. Retrospective observational study including data from 270 outpatients between 2014 and 2015. The patients were divided into...

Rekasi, Jozsef., 1994: Dr. Richnovszky Andor (Szombathely, 1932.7.8.-Szeged, 1993.7.28.). Aquila a Madartani Intezet Evkonyve, 101: 255-256

Nemeth, C.; Cook, R., 2005: Hiding in plain sight: what Koppel et al. tell us about healthcare IT. Journal of Biomedical Informatics 38(4): 262-263

Azimi-Yancheshmeh, R.; Riyahi-Bakhtiari, A.; Savabieasfahani, M., 2017: Oil contamination in surface sediment of Anzali Wetland in Iran is primarily even carbon number n-alkanes. To determine the extent of oil contamination and biodegradation in Anzali Wetland of Iran, we examined aliphatic hydrocarbons in surface sediment of this area (n=20). Petroleum hydrocarbon levels (mean 1585 ± 1117; range 316 to 4358 μg g-<...

D.S.ilo, A.; Sorba, G.; Medana, C.; Fruttero, R.; Gasco, A., 1997: Furoxan derivatives as NO-donors. In this work the synthesis and the study of both the NO-donating properties and in vitro vasodilating activities of a series of water soluble furoxans are reported. Results obtained show that appropriate substitution on the furoxan ring allows mod...

Rod, J.; Pesek, J., 1973: Cultivar-environment interaction in agrotechnical experiments with winter wheat. In a trial during 2 years [see preceding abs.], there was a significant interaction between cultivars and tillage methods, which was attributed to variation between cultivars in yield stability. Yield stability data showed that it was the same wit...

Schnell, I.; Langer, B.; Söntjens, S.H.; van Genderen, M.H.; Sijbesma, R.P.; Spiess, H.W., 2001: Inverse detection and heteronuclear editing in 1H-15N correlation and 1H-1H double-quantum NMR spectroscopy in the solid state under fast MAS. Signal enhancement in heteronuclear correlation spectra as well as signal selection in 1H experiments can be achieved through inverse, i.e., 1H, detection in the solid state under fast MAS conditions. Using recoupled polarization transfer (REPT),...