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Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats


, : Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats. Clinical and Experimental Pharmacology & Physiology 32(8): 681-686

1. The aim of the present study was to investigate the possible hypothalamic antihypertensive effect of metoprolol and its action on aminergic neurotransmission in sham-operated (SO) rats and aortic coarctated (ACo) rats at a chronic hypertensive stage using the microdialysis technique.2. Hypothalamic metoprolol concentrations and their cardiovascular effects were measured after the intravenous administration of 3 mg/kg metoprolol.

US$19.90

PMID: 16120197

DOI: 10.1111/j.0305-1870.2005.04250.x


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