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Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice


, : Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Molecular and Cellular Biology 25(9): 3563-3574

The inhibitor of differentiation Id2 is a target of the retinoblastoma (Rb) protein during mouse embryogenesis. In Rb+/- mice, LOH at the wild-type Rb allele initiates pituitary adenocarcinoma, a tumor derived from embryonic melanotropes. Here we identify a critical role for Id2 in initiation, growth, and angiogenesis of pituitary tumors from Rb+/- mice. We show that proliferation and differentiation are intimately coupled in Rb+/- pituitary cells before tumor initiation.

US$19.90

PMID: 15831462

DOI: 10.1128/MCB.25.9.3563-3574.2005


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