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Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

, : Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. Journal of Clinical Investigation 116(6): 1642-1650

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of beta -glucans and chitin. We demonstrate that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation.


PMID: 16710478

DOI: 10.1172/JCI27114

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