+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Increased expression of MUC1 in advanced pancreatic cancer

, : Increased expression of MUC1 in advanced pancreatic cancer. Journal of Gastroenterology 38(12): 1162-1166

Background: MUC1 is associated with tumor invasion and metastasis, and is expressed in pancreatic cancer with a high frequency. This study explored whether MUC1 expression affected the survival of patients with pancreatic cancer. Methods: Tissue specimens obtained from 70 patients with invasive ductal carcinoma of the pancreas, in pTNM stage III or IV, were immunostained with the anti-MUC1 monoclonal antibody DF3. The results of immunostaining were determined to be positive when more than 50% of the total cancer cells were positively stained. Association of the expression of the DF3 epitope with clinicopathological parameters or patients' survival was statistically evaluated. Results: The incidence of positivity of MUC1 expression was 55.7% (39/70) and this incidence was significantly higher in pTNM stage IV than in stage III (odds ratio (OR), 4.015; 95% confidence interval (CI), 1.459-11.0541; P=0.0076). As there was a clear difference in overall survival between pTNM stages III and IV (P=0.0016), the effect of MUC1 expression on survival was separately evaluated in each stage. It was shown that the expression of MUC1 was associated with unfavorable overall survival in stage IV (P=0.0197). Conclusions: Our data suggest that the expression of MUC1 may be related to the progression of pancreatic cancer.


PMID: 14714254

DOI: 10.1007/s00535-003-1224-6

Other references

Williams, A.P.; Smith, R.H., 1974: The amino acid requirements of the ruminating calf. Proceedings of the Nutrition Society 33(2): 35a-36a

Motzkus F.; Bachmann D., 1968: Origin and interpretation of the inst radio renogram. Nuclear Medizin 7(1): 46-58

Wright, S.Paul, 1992: Adjusted P-values for simultaneous inference. This paper proposes that results from simultaneous tests be reported as adjusted P-values such that, if the adjusted P-value for an individual hypothesis is less than the chosen significance level of alpha, then the hypothesis is rejected with an...

O'Connor, R.C.; Ferguson, E.; Scott, F.; Smyth, R.; McDaid, D.; Park, A-La.; Beautrais, A.; Armitage, C.J., 2017: A brief psychological intervention to reduce repetition of self-harm in patients admitted to hospital following a suicide attempt: a randomised controlled trial. We investigated whether a volitional helpsheet (VHS), a brief psychological intervention, could reduce repeat self-harm in the 6 months following a suicide attempt. We did a prospective, single-site, randomised controlled trial. Patients admitted...

Wilkinson, J.M.; Pollard, I., 1993: Immunohistochemical localisation of the 90, 70 and 25 kDa heat shock proteins in control and caffeine treated rat embryos. Human and animal experimental data demonstrate that in utero exposure to caffeine results in intrauterine growth retardation and long-term behavioural and reproductive effects. We have suggested that the disruption of normal transcription and tran...

Miura, K.; Nakamura, H.; Tamura, Z., 1981: Improvement of the parallel flow dialysis technique for the detection of drug-binding proteins in column effluents. The parallel flow dialysis technique was improved for application to the detection of drug-binding proteins in a column chromatographic effluent. To prevent the baseline drift, the pressures of both protein and drug channels were maintained equal...

Rodler, D.; Sinowatz, F., 2013: Expression of intermediate filaments in the Balbiani body and ovarian follicular wall of the Japanese quail (Coturnix japonica). In the present study, we examined the distribution of 6 groups of intermediate filaments (IFs; cytokeratins, CKs, vimentin, synemin, desmin, glial fibrillary acidic protein and lamins) in oocytes and follicular walls of the Japanese quail (Coturni...

Anonymous, 2012: Detailed Description of Morphology of the Last Instar Larva and Pupa of Apsectus hystrix Sharp, 192 Dermestidae Trinodinae Trinodini. The first description of the larva of <i>Apsectus hystrix</i> <a onclick="showRef(this, 'bibr17'); return false;" href="JavaScript:void(0);" class="ref">Sharp, 1902</a> (Coleoptera: D...

Ivanov, L.A.; Silina, A.A.; Zhmur, D.G.; Tselniker, Yu. L., 1953: Determination of transpiration loss by a forest timberstand. KEYWORDS: plant \ physiology \ plant physiology \ physiology \ plant physiology \ Transpiration measurement

Bobodzhanov, V.A.; Kurbanova, M.B.; Borotova, M., 1990: Yield production process in hexaploid triticales. In a comparison of 2 tall and 2 short triticales with wheat (Siete Cerros) and rye (Vakhshkaya 116), all the genotypes differed from each other in net photosynthetic production: at the initial stages of development, the tall triticale Nemiga 2 had...