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Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice

, : Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice. Radiation Research 165(6): 671-677

Smad3 protein is a prominent member of the Tgfb receptor signaling pathway. Smad3(-/-) mice display decreased radiation-induced skin fibrosis, suggesting a defect in both Tgfb-mediated fibroblast proliferation and migration. We established bone marrow stromal cell lines from Smad3(-/-) mice and homozygous littermate(+/+) mice. Smad3(-/-) cells displayed a significant increase in radiation resistance with a D-0 = 2.25 +/- 0.14 Gy compared to Smad3(+/+) cells with a D-0 = 1.75 0.03 (P = 0.023).


PMID: 16802867

DOI: 10.1667/RR3572.1

Other references

Kim, S-Soo.; Sun Park, M.; Jeon, O.; Yong Choi, C.; Kim, B-Soo., 2005: Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biodegradable polymer/bioceramic composite scaffolds call overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. However, conventional methods for fabricating polymer/bioceramic composite s...

Fosberg, FR., 1975: The Axis deer problem. Elepaio, 328: 86-88

Santos, M.; Marcos, R.; Roccabianca, P., 2017: The blood cell family on a lymph node road. Veterinary Clinical Pathology 46(2): 209-210

H.I.o; K.T.kieda; K.S.wa;, 1978: Remanent magnetization of Precambrian and Cretaceous kimberlites in South Africa. Geophysical Journal International 55(1): 123-130

Anderson, M.J.; Butcher, J.E., 1975: Metabolism of cubed feeds by sheep with various concentrate:forage ratios. Diets of cubed or chopped hay only or with 25 or 50% rolled barley were given to mature wether sheep in a 2 X 3 factorial experiment. Crude protein and ash contents of the cubed diets were higher than those of the chopped diets. Digestibility of D...

Pond, C.D.; Holden, J.A.; Ireland, C.M.; Barrows, L.R., 1996: Steady-state kinetic analysis of drug-DNA-topoisomerase I interactions. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 435

Svensson, H., 1990: Relict periglacial structures. Occurrences, age and development in different matrices on a coastal plain of southwestern Sweden. Observations of relict periglacial structures were made in a 40 km long pipeline section through a coastal plain of southwestern Sweden. Ice-wedge formation and wedge characteristics in a broad range of matrices (glaciofluvium, glaciomarine sedime...

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Verbitskiĭ, V.M.; Mirskiĭ, M.B.; Khil'chenko, M.A., 1986: History of the creation of the 1st midwife schools in Russia. Fel'dsher i Akusherka 51(3): 51-53

Schaerer U.; Corfu F.; Demaiffe D., 1992: Subcontinental mantle heterogeneities; U/ Pb and Lu/ Hf in baddeleyite and zircon of the Mbuji-Mayi Kimberlite. Reunion Annuelle des Sciences de la Terre 14: 139