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Insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E


, : Insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E. Biochemical Journal 382(Pt 3): 987-994

APP (amyloid precursor protein), together with Chol (cholesterol) and ApoE (apolipoprotein E), has been linked to Alzheimer's disease. We have examined the hypothesis that interaction of APP with the lipid membranes is modulated by Chol and ApoE. Insertion of APP into lipid monolayers was first evidenced as an increase in the surface pressure.

US$19.90

PMID: 15202933

DOI: 10.1042/BJ20040777


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