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Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

, : Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants. Genes and Immunity 7(1): 65-68

We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6174CC- genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6174GG (n = 430) 8%, IL-6-174GC ( n = 605) 9% and IL-6-174CC ( n = 167) 12% ( P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers ( n = 157), 26% of IL-6-174GC-carriers ( n = 193) and 27% of infants carrying the IL-6-174CC- genotype ( n 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.


PMID: 16208404

DOI: 10.1038/sj.gene.6364264

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