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Interpretation of protein folding psi values

, : Interpretation of protein folding psi values. Journal of Molecular Biology 351(2): 393-401

The structural characterization of transition states is essential for understanding the mechanism of protein folding. Analyzing the effect of mutations on protein stability and folding kinetics in phi-value analysis is commonly used to gain information about the presence of side-chain interactions in transition states. Recently, specific binding of ligands to engineered binding sites was applied to monitor the formation of local structures in transition states (analysis).


PMID: 16005895

DOI: 10.1016/j.jmb.2005.05.062

Other references

Pan, X.; Glatz, C.E., 2000: Effects of salts and surface properties of proteins on the growth rate of subtilisin crystals. Abstracts of Papers American Chemical Society 219(1-2): BIOT 174

Browne, Rory., 1998: Of bears, belugas and brahmins: the historic relations and future mission of zoos and aquaria. American Zoo and Aquarium Association Regional Conference Proceedings, 419-424

Wang, J.; Shi, M.; Xia, Y.; Luo, S.; Fu, X.; Xiao, F.; Li, J.; Deng, Z.; Long, X., 2011: Three-dimensional conformal radiation therapy for refractory laryngeal granuloma. The etiology of laryngeal granulomas is often multifactorial and the benefit of pharmacological therapy remains unclear. Anti-reflux treatment is only effective in granulomas definitely induced by gastroesophageal reflux. Steroid inhalation has sh...

Wallis, Y.; Morrell, N., 2011: Automated DNA sequencing. Fluorescent cycle sequencing of PCR products is a multistage process and several methodologies are available to perform each stage. This chapter will describe the more commonly utilised dye-terminator cycle sequencing approach using BigDye® termi...

Peschen-Rosin, R., 2002: Chronic facial pain from psychiatric point of view - differential diagnosis and therapeutic strategies. Chronic facial pain may cause diagnostic and therapeutic difficulties, thus demanding a complete interdisciplinary consultation. As in 20 to 25% of patients with a nociceptive or primary neuropathic pain a psychiatric comorbidity is expected, it i...

Boerner, R.J.; Consler, T.G.; GampeRobert T.Jr.; Weigl, D.; Willard, D.H.; Davis, D.G.; Edison, A.M.; LoganzoFrank, J.; Kassel, D.B.; Xu, R.X.; Patel, I.R.; Robbins, J.S.; Lansing, T.; Gilmer, T.M.; Luther, M.A.; Knight, W.B., 1995: Catalytic activity of the SH2 domain of human pp60-c-src; evidence from NMR, mass spectrometry, site-directed mutagenesis and kinetic studies for an inherent phosphatase activity. During solution structural studies it was apparent that the human recombinant pp6O-c-src SH2 domain (srcSH2, residues 144-249) possessed an inherent phosphatase (Pase) activity. Complexes of U(13C,15N)srcSH2 with unlabeled Ac-pYEEIE (I) were exami...

Lebreton,S.; Chevrier,C.; Darrouzet,E., 2010: Sex allocation strategies in response to conspecifics offspring sex ratio in solitary parasitoids. Parasitoid females adjust their offspring sex ratio in order to maximize their fitness. The optimal sex ratio they produce varies with several factors but especially with competition level. In solitary species, only one adult can emerge from a giv...

Zhang, X.; Badea, C.; Hood, G.; Wetzel, A.; Qi, Y.; Stiles, J.; Johnson, G.Allan., 2011: High-resolution reconstruction of fluorescent inclusions in mouse thorax using anatomically guided sampling and parallel Monte Carlo computing. We present a method for high-resolution reconstruction of fluorescent images of the mouse thorax. It features an anatomically guided sampling method to retrospectively eliminate problematic data and a parallel Monte Carlo software package to compu...

Cruz M., 1980: The role of slime material of xanthomonas vesicatoria in the development of bacterial blight of tomato. Acta Microbiologica Academiae Scientiarum Hungaricae: 255

Holler, C.; Haardt, H., 1993: Low field performance of an aphid parasitoid, Aphelinus abdominalis, efficient in the laboratory (Hym., Aphelinidae). Life history traits of 2 inbred lines of the parasitoid Aphelinus abdominalis were evaluated in the laboratory. Both lines were very fecund, produced a large proportion of female offspring and were long-lived. However, release experiments in winte...