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Invadopodia and podosomes in tumor invasion


, : Invadopodia and podosomes in tumor invasion. European Journal of Cell Biology 85(3-4): 213-218

Cell migration through the extracellular matrix (ECM) is necessary for cancer cells to invade adjacent tissues and metastasize to an organ distant from primary tumors. Highly invasive carcinoma cells form ECM-degradingy membrane protrusions called invadopodia. Tumor-associated macropliages have been shown to promote the migratory phenotypes of carcinoma cells, and macrophages are known to form podosomes, similar structures to invadopodia. However, the role of invadopodia and podosomes in vivo remains to be determined. In this paper, we propose a model for possible functions and interactions of invadopodia and podosomes in tumor invasion, based on observations that macrophage podosomes degrade ECM and that podosome formation is regulated by colony-stimulating factor-l signaling. Published by Elsevier GmbH.

US$19.90

PMID: 16546563

DOI: 10.1016/j.ejcb.2005.10.004


Other references

Magnusson, C., 1983: Abundance, distribution and feeding relations of root. Holarctic ecology 6(2): 183-193

Dumon, M.F.; Camare, R.; Nassar, B.B.; Dang, Q.Q.; Clerc, M., 1990: Discontinuous polyacrylamide gel-agarose gel immunoelectrophoresis for analysis of plasma lipoproteins. A modification of crossed immunoelectrophoresis for the analysis of plasma lipoproteins is described and is called polyacrylamide gel-crossed immunoelectrophoresis. The incorporation of albumin in the first-dimensional gel facilitates the transfer...

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Nakayama, K., 1992: Studies on pathogenesis of intractable asthma part 1. characteristics of clinical and immuno pathological findings in intractable asthma. To clarify the pathogenesis of intractable asthma, clinical features, allergic examinations, pulmonary functions and histological findings were evaluated in 27 intractable asthmatics compared with 33 non-intractable asthmatics. Almost all of the i...

Peden, N.R.; Pringle, S.D.; Crooks, J., 1982: The problem of psilocybin mushroom abuse. The clinical features and management of 44 consecutive patients presenting over a 5 week period during an outbreak of ingestion of psilocybin-containing mushrooms are reviewed. Patients presented usually because of dysphoric effects an av. of 3.8...

Carmona-Fonseca, J., 2004: Reference values for erythrocyte cholinesterase activity in the working population of Antioquia, Colombia, according to the Michel and EQM techniques. To establish reference values for erythrocyte cholinesterase (EC 3.1.1.7) activity for the active working population of two regions of the department of Antioquia, Colombia, that are located at different altitudes above sea level. We took represen...

Kalyakin, V.N., 1999: The nesting of Iceland Gull at Novaya Zemlya, North Russia. New data on the nesting of Iceland gull at Novaya Zemlya and description of the two specimens from Bezymannaya and Puhovaya Bays are presented. According with the data of 1993 and 1994 seasons this species allocates along the western coast of the...

Sinska, J.; Bezova, K., 1977: Storage of lucerne blossoms in order to lengthen pollen vitality. Flowers were put in bags of paper(p), cellophane (c), and igelit (i). The bags were stored: in an exsiccator (E) above silicagel in a freezer at 0 + 2.degree. C temperature and relative air humidity about 20%; in a freezer (M) at 0 + 2.degree. C t...

Fusman, B.; Jolly, N.; Feldman, T., 2000: Use of pressure wire to measure gradients across aortic valve. American Journal of Cardiology 86(Suppl 8A): 68i, October 16