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Involvement of protein kinase Cdelta and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-(3,4-dimethoxycinnamoyl)-antranilic acid (tranilast)


, : Involvement of protein kinase Cdelta and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-(3,4-dimethoxycinnamoyl)-antranilic acid (tranilast). Biochemical Pharmacology 66(7): 1263-1270

Excess nitric oxide (NO) in the brain released by microglial cells contributes to neuronal damage in various pathologies of the central nervous system (CNS) including neurodegenerative diseases and multiple sclerosis. N-(3,4-Dimethoxycinnamoyl)-anthranilic acid (tranilast, TNL) is an anti-allergic compound which suppresses the activation of monocytes.

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Li, C.H.; Stratford, R.E.; Velez de Mendizabal, N.; Cremers, T.I.F.H.; Pollock, B.G.; Mulsant, B.H.; Remington, G.; Bies, R.R., 2015: Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics. Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug. To better understand this variability, the objective of this study was to predict brain extracellular...