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Isolation and structure analysis of streptomyces polysaccharide with inhibit HIV envelope glycoprotein subunit gp41 activity


, : Isolation and structure analysis of streptomyces polysaccharide with inhibit HIV envelope glycoprotein subunit gp41 activity. Zhongguo Yaolixue Tongbao 21(3): 283-288

Aim To isolate, purify, and chemically characterize a polysaccharide showing inhibition of the six-alpha-helix bundle formation of HIV-1 envelope glycoprotein gp41 from cultured broth of a streptomyces sp. strain. Methods Ethanol was used to precipitate polysaccharides and macromolecules from the broth. Proteins in the precipitate were removed by sevage method. Purification was carried out by DEAE-Cellulose and sephadex G-25 column chromatography.

US$29.90


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