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Jonctions communicantes et cancer: Implications et perspectives


, : Jonctions communicantes et cancer: Implications et perspectives. M S (Medecine Sciences) 20(2): 197-206

Gap junctions are made of intercellular channels which permit the diffusion from cytoplasm to cytoplasm of small hydrophilic molecules (<1 200 Da) such as ions, sugars, aminoacids, nucleotides, second messengers (calcium, inositol triphosphate, etc.). Since their discovery in the early sixties, several groups have described the loss of their function in cancer cells. The accumulation of such data led to the hypothesis that gap junctions are involved in the carcinogenesis process.

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Piazzini, A.; Canger, R., 2001: Depression and anxiety in patients with epilepsy. Epilepsia 42 Suppl 1: 29-31; Discussion 35-6

Bodde, H.E.; Roemele, P.E.H.; Star, W.M., 2002: Quantification of topically delivered 5-aminolevulinic acid by iontophoresis across ex vivo human stratum corneum. Iontophoretic transport of the prodrug 5-aminolevulinic acid (ALA), which is used for photodynamic therapy (PDT), across human stratum corneum (SC) was studied quantitatively in vitro. The experiments were carried out in a three-compartment iontop...

Yastrebov, N., 1954: Automatic equipment for the manufacture of processed cheese. This illustrated account describes a mechanism which stops the work of a cheese-packing machine should the supply of wrapping materials fail.

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Gordh, G.; Barrows, E.M., 1976: Uropoda phoretic on ceratina acarina hymenoptera. Additional documentation of phoresy by a species of mite in the genus Uropoda with a heretofore unreported dispersal agent, Ceratina metallica Smith, is reported. A phoresitized female of C. metallica was collected from the head of Arctium minus B...

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Moser, M.; Stempfl, T.; Li, Y.; Glynn, P.; Buettner, R.; Kretzschmar, D., 2000: Cloning and expression of the murine sws/NTE gene. The Drosophila neurodegeneration gene swiss-cheese encodes a neuronal protein apparently involved in glia-neuron interaction and is homologous to human NTE, the molecular target of organophosphate-induced neuropathy. The isolated Msws/NTE gene is...

Simpson, H.; Barker, K., 2002: Effect on knee flexion of a modification to the surgical technique of pin placement during femoral lengthening. Loss of knee movement is a common problem in femoral lengthening. Two groups of 10 children were compared: one group lengthened by the Ilizarov technique using a standard method and one group in whom the technique was modified to incorporate a dif...

Myburgh, W.J.; Westfall, R.H., 2004: A model for predicting the width of the riparian zone. A simple linear model for predicting the width of the riparian zone in terms of channel width and bank slope was used to describe the Olifants River system in South Africa. Information recorded includes the degree to which the riparian zone can be...