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Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets


, : Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Developmental Cell 8(6): 843-854

beta-catenin-dependent or canonical Writ signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kalso directly represses canonical Writ gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to P-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois.

US$19.90

PMID: 15935774

DOI: 10.1016/j.devcel.2005.04.010


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