geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors


, : Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors. Journal of Immunology 175(6): 4076-4083

Isolated hepatic perfusion of nonresectable liver cancer using the combination of TNF and melphalan can be associated with a treatment-related hepatotoxicity. We investigated whether, apart from TNF, also melphalan is cytotoxic in primary murine liver cells in vitro and investigated mediators, mode of cell death, and cell types involved. Melphalan induced a caspase-dependent apoptosis in hepatocytes, which was not seen in liver cell preparations depleted of Kupffer cells.

US$19.90

PMID: 16148157

DOI: 10.4049/jimmunol.175.6.4076


Other references

Cohen, J.H.; Haas, J.D., 1999: Estimating the iron stores of a sample of Costa Rican infants and a sample of infants from the NHANESIII survey between the ages of 12 and 23 months. FASEB Journal 13(5 PART 2): A697, March 15

Rajgopal, A.; Vasdev, A.; Dahiya, V.; Tyagi, V.C.; Gupta, H., 2013: Total knee arthroplasty in extra articular deformities: A series of 36 knees. The presence of extra articular deformities either in the femur or the tibia with arthritis of the knee makes total knee arthroplasty (TKA) technically demanding. The purpose of this study is to report outcomes with Total Knee Arthroplasty in pati...

Felsenthal, S.; Stamm, C., 1894: Die Veranderungen in Leber und Darm bei der Coccidienkrankheit der Kaninchen. Arch Pathol Anat, cxxxii 36-49

Anonymous, 1993: What is your recommendation concerning the vaccination of an employee who will be traveling for 3 months in a country that is considered a rabies-endemic area?. Journal of Occupational Medicine. 35(9): 884-885

Gray, D.; Zytner, R.; Stiver, W., 1994: Soil remediation using supercritical carbon dioxide. Proceedings of the Industrial Waste Conference8(48): 179-185

Sabaa A.T.; Howard W., 2001: Pliocene foraminiferal biostratigraphy and paleoceanography of ODP Site 1125, eastern New Zealand. Geological Society of New Zealand Miscellaneous Publication 110A: 134

Mcdaniel, N.; Lytle, C., 1999: The Na-K-2Cl cotransporter is selectively expressed in downwardly-migrating gastric parietal cells. FASEB Journal 13(5 PART 2): A1012, March 15

Reid, A.E.; Carey, K.B.; Merrill, J.E.; Carey, M.P., 2016: Social network influences on initiation and maintenance of reduced drinking among college students. To determine whether (a) social networks influence the extent to which college students initiate and/or maintain reductions in drinking following an alcohol intervention and (b) students with riskier networks respond better to a counselor-delivere...

Lis, G., 2010: Can allergy be prevented in children? Environmental intervention. Introduction. Allergic diseases, especially these IgE-dependent, have multifactorial origin, so genetic and environmental factors play role in their development. Increased prevalence of these diseases in last decades indicates that environmental stimuli play th...

Rowlerson, A.; Radaelli, G.; Mascarello, F.; Veggetti, A., 1997: Regeneration of skeletal muscle in two teleost fish: Sparus aurata and Brachydanio rerio. Regeneration of skeletal muscle was studied in the sea bream Sparus aurata, in which extensive post-larval muscle hyperplasia contributes to its large adult size, and in the zebrafish Brachydanio rerio, which shows little post-larval hyperplasia a...