geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression


, : Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Human Pathology 36(5): 555-561

We tested the hypothesis that PTEN inactivation may stratify cancer progression risk among putative endometrial hyperplasias, classified prognostically by means of the morphometric D score (DS). The DS, calculated from 3 morphometric variables measured in routine hematoxylin-eosin-stained endometrial biopsy slides, is the most sensitive and specific method of endometrial cancer risk prediction currently available. Clinical outcornes of 103 women with endometrial hyperplasia on biopsy were tallied according to the DS. Seven (7/103; 7%) patients with carcinoma during follow-up were all distributed within the high-risk prognostic group (ie, DS < 1 = endometrial intraepithelial neoplasia [EIN]) (7/21; 33% progression). None of the 82 cases with a DS higher than I progressed. All cases that progressed were PTEN null, indicating that this genotype is capable of further stratifying cancer progression risk in hyperplasias irrespective of histological categorization. However, only 16% of the PTEN-null cases progressed. When PTEN expression pattern was combined with EIN, the prognostic power was greatly increased (specificity from 63% for PTEN and 85% for EIN to 93% when combined; positive predictive value from 16% and 33% to 50%). We conclude that loss of PTEN expression is the first biomarker in EIN that increases the accuracy of the prognostic DS to predict cancer progression risk. Unless endometrial hyperplasias are stratified by histological inorphornetric D-Score, PTEN has a low positive predictive value. (c) 2005 Published by Elsevier Inc.

US$19.90

PMID: 15948123

DOI: 10.1016/j.humpath.2005.02.018


Other references

Tanabe, S.; Nakatani, T.; Han, Y.; Kishimoto, T.; Ohishi, M.; Ogami, M.; Ikura, Y.; Ueda, M., 2001: Enhanced expression of angiotensin II type 1 receptor in the neointima of transplant renal arteriosclerosis in human renal allografts. Transplantation Proceedings 33(1-2): 1172-1174

Hollanders, R.M.F.; Van Ewijk Beneken Kolmer, E.W.J.; Burger, D.M.; Wuis, E.W.; Koopmans, P.P.; Hekster, Y.A., 2000: Determination of nevirapine, an HIV-1 non-nucleoside reverse transcriptase inhibitor, in human plasma by reversed-phase high-performance liquid chromatography. A sensitive and rapid high-performance liquid chromatography method has been developed to measure the levels of the HIV-1 non-nucleoside reverse transcriptase inhibitor nevirapine in human plasma. The sample pre-treatment consists of a protein pre...

Clusius, K., 1963: The history of metric measure. The history of the normal meter shows distinct steps of development. The meter itself was defined by French scientists as a national unit at the beginning of the French Revolution and realized in 1799 by a platinum rod. A better reproduction of th...

Patrzalek A.; Bogdanowki J.; Myczkowski Z., 1998: Structural landscaping in a recreation park site on a mining waste dump in Bierun Nowy (Upper Silesia). This study is an attempt to address matters associated with the proposal to create a new element in the municipal green belt system of Bierun Stary and Bierun Nowy. Former documents developed by the authors of the present study considered a propos...

Zhang, H.; Dong, Y.; Leeson, J.; Chen, L.; Bao, X., 2011: High sensitivity optical fiber current sensor based on polarization diversity and a Faraday rotation mirror cavity. A novel high sensitivity optical fiber current sensor (OFCS) based on polarization diversity and a Faraday rotation mirror cavity is proposed and demonstrated. Comparing with single-channel detection in a conventional OFCS, a signal power gain of...

Khan, I.; Bhat, R.A.; Khan, I.; Hameed, I., 2015: Grave's disease associated with immunoglobulin A nephropathy: A rare association. Immunoglobulin A (Ig A) nephropathy is the most common form of primary glomerulonephritis. The association of Ig A nephropathy with Grave's disease has not been reported so far. We report a case of 20-year-old female with Grave's disease...

Anon., 1953: Avocado of the future. A Californian nurseryman has developed a method of growing avocado trees on 2 seedling rootstocks instead of one. He claims that this will double the chances of getting economically productive trees. The double-rooted trees will be tested in a con...

Jansen, J.; Gres, P.; Umschlag, C.; Degenhardt, H.; Schlueter, K.D.eter; Heusch, G., 2001: Parathyroid hormone-related peptide improves regional contractile function of the stunned myocardium in pigs. Circulation 104(17 Supplement): II 569, October 23

Brown, W.E.; Rodwell, V.W., 1983: Purification and properties of two native, high-molecular-weight hydroxymethylglutaryl-CoA reductase phosphatases. Biochimica et Biophysica Acta 751(2): 218-229

Kumar, M.; Raman, R.; Prepagaran, N.; Krishnan, G., 2002: Use of aural speculum in epistaxis. British Journal of General Practice 52(476): 234-234