+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Left ventricular noncompaction: a pathological study of 14 cases

, : Left ventricular noncompaction: a pathological study of 14 cases. Human Pathology 36(4): 403-411

Left ventricular noncompaction (LVNC) has been recently proposed as a specific form Of cardiomyopathy. There have been few pathological series describing gross and microscopic findings of this entity, especially in children. We present findings of 14 hearts (13 autopsy and 1 explant) with LVNC (isolated and associated with congenital heart disease), defined by poorly developed left ventricular (LV) papillary muscles and a noncompact inner LV myocardial layer comprising more than 50% of the LV thickness. The mean age at death/explant was 3.6 years (median, 2.5 months); there were 6 boys and 8 girls. The symptoms were sudden unexpected death (10) and heart failure (4). The diagnosis was suspected before death in only I of 13 autopsy cases. Right ventricular involvement (> 75% ventricular thickness comprised of noncompacted area with recess adjacent to tricuspid valve) was seen in 6 of 14 hearts. One patient had a sibling with pulmonary stenosis, but there was no other known familial cardiomyopathy. Endocardial fibroelastosis was a characteristic histological feature, as well as anastomosing or polypoid endocardial trabeculations, which resulted in staghorn-shaped, endocardial-lined recesses. There was a high rate of other cardiac anomalies, which often coexisted and were not clearly related to the LVNC, present in 8 cases (nonisolated LVNC): ventricular septal defect (4/14), anomalous venous pulmonary veins (1/14), coronary ostial stenosis (1/14), histiocytoid cardiomyopathy (1/14), polyvalvar dysplasia, (2/14), and pulmonary stenosis (2/14). In the 6 isolated LVNC, there were 2 malformed atrioventricular valves (1 mitral and 1 tricuspid), which appeared part of the ventricular maldevelopment. There were no differences in histological or gross patterns of the noncompacted regions between the isolated and nonisolated LVNC. LVNC is frequently associated with other cardiac defects, especially when causing sudden death in infants and children. A clear-cut morphological distinction between "isolated" and "secondary" LVNC was not apparent. The pathologist should be aware of the entity because the diagnosis is often first established at autopsy. (c) 2005 Elsevier Inc. All rights reserved.


PMID: 15892002

DOI: 10.1016/j.humpath.2005.02.004

Other references

Redfield A.G.; Moleski C., 1972: Vibrating sample magnetometer for protein research. Review of Scientific Instruments 43(5): 760-762

Resnick, S.B.; Pillion, J.P.; Heinz, J.M., 1985: Effects of frequency modulation on absolute, masked, and reflex thresholds. Behavioral and acoustic reflex thresholds were determined for five normal-hearing subjects in response to carrier signals of 500 and 2000 Hz which were unmodulated or modulated sinusoidally at rates of 2, 20, and 200 times per second with frequenc...

Ehrich, D.; Cerezo, M.; Rodnikova, A.Y.; Sokolova, N.A.; Fuglei, E.; Shtro, V.G.; Sokolov, A.A., 2017: Vole abundance and reindeer carcasses determine breeding activity of Arctic foxes in low Arctic Yamal, Russia. High latitude ecosystems are at present changing rapidly under the influence of climate warming, and specialized Arctic species at the southern margin of the Arctic may be particularly affected. The Arctic fox (Vulpes lagopus), a small mammalian p...

Weinstock, C.; Campassi, C.; Goloubeva, O.; Wooten, K.; Kesmodel, S.; Bellevance, E.; Feigenberg, S.; Ioffe, O.; Tkaczuk, K.H.R., 2015: Breast magnetic resonance imaging (MRI) surveillance in breast cancer survivors. As the breast cancer survivor population increases, the topic of screening these women for recurrences is increasingly relevant. In our institution, we use both breast MRI and mammography in the surveillance of breast cancer survivors, although li...

Clavica, F.; Zhao, X.; ElMahdy, M.; Drake, M.J.; Zhang, X.; Carugo, D., 2014: Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model. Double-J stenting is the most common clinical method employed to restore the upper urinary tract drainage, in the presence of a ureteric obstruction. After implant, stents provide an immediate pain relief by decreasing the pressure in the renal pe...

Sharpe, S.W.; Kelly, J.F.; Hartman, J.S.; Gmachl, C.; Capasso, F.; Sivco, D.L.; Baillargeon, J.N.; Cho, A.Y., 2007: High-resolution (Doppler-limited) spectroscopy using quantum-cascade distributed-feedback lasers. Lasing characteristics were evaluated for distributed-feedback quantum-cascade (QC) lasers operating in a continuous mode at cryogenic temperatures. These tests were performed to determine the QC lasers' suitability for use in high-resolution...

Anonymous, 2013: Proceedings of The 13th International Conference on Trichinellosis, August 1–6, 2011, Changchun, China. Veterinary Parasitology 194(2-4): 99-221

Bouattour, K.; Moyano-Tidou, G.; L.G.uez, A.; Martel-Jacob, S.; Mercier, F-J., 2015: Epidural bleeding after labor epidural analgesia. Anaesthetists often stand in the front line to manage postpartum neurological deficits, although epidural analgesia is rarely responsible for these complications. An epidural analgesia was performed to relieve pain during spontaneous labor in a 34...

Arredondo García, J.L., 1987: AIDS: extent of the problem. Practica Odontologica 8(6): 42-44

Berlit, P., 1988: The prognosis and long-term course of viral encephalitis. Of 33 patients with viral encephalitis, four (three women, one man) succumbed to the disease. Of the surviving patients, 23 were followed for a median interval of 4 years after discharge. A considerable residual syndrome could be detected in two c...