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Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir

, : Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir. Infection 32(4): 229-233

Background: Lipoprotein disorders in HIV-positive patients receiving highly active antiretroviral therapy (HAART) are becoming a major concern in HIV treatment, since there is growing evidence for an association between HAART-induced hyperlipidemia and increased cardiovascular risk. Yet relatively few data are available on the possible interactions of HAART and treatment with statins. Patients and Methods: In this prospective study, 25 HIV-positive, treatment-experienced patients (five female, 20 male, all Caucasian) were treated with either fluvastatin or pravastatin. Total cholesterol, Low density Lipoprotein (LDL) and high density lipoprotein (HDL) levels, and serum triglycerides were determined at regular intervals, as well as therapeutic drug monitoring to assess possible drug interactions. Results: In 13 pravastatin-treated patients, a decrease in total cholesterol levels (from 7.12 mmol/l to 6.29 mmol/l) after 12 weeks of therapy was seen. In 12 patients treated with fluvastatin, a permanent reduction of total cholesterol (from 6.46 mmol/l to 5.31 mmol/l) after 12 weeks was observed. The reduction of LDL Levels was 30.2% in the fluvastatin group and 14.4% in the pravastatin group. In eight patients receiving an indinavir-containing HAART, indinavir plasma Levels were not significantly influenced. No effect on triglycerides or HDL was observed. Conclusion: Fluvastatin and pravastatin are efficient in Lowering total and LDL cholesterol Levels in HIV-positive patients receiving HAART. Furthermore, no influence on indinavir plasma levels could be observed. Therefore, both compounds seem to be a viable treatment option in HAART-induced hypercholesterolemia.


PMID: 15293079

DOI: 10.1007/s15010-004-3136-7

Other references

Chow, L.T.; Lee, K.C., 1992: Intraosseous lipoma. A clinicopathologic study of nine cases. Intraosseous lipoma is one of the rarest benign primary tumors of the bone. The clinicopathologic features of nine cases of intraosseous lipoma, including one with multiple lesions of the lumbar spinous processes, were studied and analyzed. They r...

Kang, D-Wei.; Zhao, Z-Jiang.; Guo, W-Xia.; Tan, L-Yi.; Kang, W.; Li, J-Qing., 2012: Habitat selection attributes of giant panda. Based on the 1997-2009 inventory data of Wanglang Nature Reserve, the habitat selection attributes of giant panda were studied from the aspects of topography, forest community structure, and main feeding bamboo by the methods of frequency distribu...

Antolic V., 1980: Anion transport and ph dependence of red blood cell volume. The role of the anion transport mechanism in the RBC (red blood cell) whose volume change depends on medium pH was studied. A new method of measuring the RBC relative volume was introduced. The method is based on the scattering of light which is c...

Murillo, A.; López, M.A., 1971: Contribution to the study of hormonal regulation of pancreatic secretin in the rabbit. Revista Espanola de Fisiologia 27(2): 131-138

Wong, M.Y.M.; Zhang, Y.T., 2007: The variabilities of blood pressure and pulse arrival time in normotensive young subjects under dynamic conditions. Investigators are paying more attention to blood pressure variability (BPV) because of its associations with target-organ damage in hypertensive subjects and cardiovascular morbidity. In spite of its importance, parameter for continuous and non-in...

Leslie M.H.; Gill F.M.; Cooper R.A., 1978: The fluidity of hereditary spherocytosis red cell membranes is normal. Clinical Research 26(3): 351A

Hoyer, D.; Pazos, A.; Probst, A.; Palacios, J.M., 1986: Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. The presence, pharmacological properties and anatomical distribution of serotonin-1A and serotonin-1B receptor subtypes were studied in the human brain by both radioligand binding assays and autoradiographic procedures. Frontal cortices and hippoc...

Royster, L.T.; Hulvey, C.N., 1929: The relations of weight, height and age in negro children. Amer Jour Dis Children 38(6): 1222-1230

Adam, R.; Astarcioglu, I.; Raccuia, J.S.; Ducot, B.; Reynes, M.; Bismuth, H., 1996: Beneficial effects of Eurocollins as aortic flush for the procurement of human livers. A review of 550 consecutively transplanted liver grafts stored in University of Wisconsin solution (UW) was performed during a 4-year period to ascertain whether graft function was impaired by flushing the aorta with Eurocollins (EC) rather than U...

Fuchs, R.; Gassen, H.G., 1989: Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase. Nucleic Acids Research 17(22): 9471-9471