geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma


, : Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma. American Journal of Ophthalmology 140(2): 236-241

Purpose: Nasopharyngeal rhabdomyosarcoma may present with a variety of ophthalmic symptoms. Direct extension of the tumor into the orbital apex can lead to ophthalmoplegia and loss of vision. The prognosis for recovery of vision and ocular motility in patients with an orbital apex syndrome due to nasopharyngeal rhabdomyosarcoma is examined.Design: Retrospective case series.Methods: Six eyes from four patients with nasopharyngeal rhabdomyosarcoma who presented to the Children's Hospital of Philadelphia with a clinical orbital apex syndrome were identified. Complete ophthalmic examination, including visual acuity and extraocular motility at the time of presentation, was reviewed. Tumor extension into the orbital apex was confirmed radio, graphically. Follow,up ophthalmic evaluations were reviewed for all patients with an average follow,up of 5.5 +/- 3.1 years (range 1 to 8 years).Results: Six eyes of four patients had limited ocular ductions along with marked loss of vision at presentation. All patients were treated with chemotherapy and radiation, with reduction of tumor mass. Ocular motility recovered in all patients, occurring by an average of 2.2 +/- 1.8 months after initiation of therapy. Four of six eyes had little or no recovery of visual acuity detected at long,term follow-up.Conclusions: Patients with ocular motor deficits in orbital apex syndromes caused by extension of nasopharyngeal rhabdomyosarcoma have an excellent prognosis for recovery after treatment of the tumor. The long-term prognosis for visual recovery, however, is poor.

US$19.90

PMID: 16023064

DOI: 10.1016/j.ajo.2005.02.054


Other references

Klinge, V.; Lachar, D.; Grisell, J.; Berman, W., 1978: Effects of scoring norms on adolescent psychiatric drug users' and nonusers' MMPI profiles. The present study compared the effects of scoring norms on adolescent psychiatric inpatient drug users' and nonusers' MMPI profiles. The results indicated that regardless of drug usage or nonusage the application of adolescent norms yiel...

Takeuchi, K.; Fukuda, A.; Kanayama, N., 2003: Effect of urinary trypsin inhibitor on potassium currents: fetus modulates membrane excitability by production of UTI. Amniotic fluid contains a significant level of urinary trypsin inhibitor (UTI). Previously, we reported that UTI inhibits calcium influx of myometrium and it is effective in preventing uterine contraction. This study examined the effects of UTI up...

Salamon, L.; Lennon, M., 2003: Decreasing companion usage without negatively affecting patient outcomes: a performance improvement project. The use of companions to monitor and care for patients at risk for adverse events is a long-standing practice with patients who require constant observation such as with suicide precautions. While offering a potential benefit of increased safety,...

Barron, C.I., 1977: High-altitude decompression exercise. Aviation, Space, and Environmental Medicine 48(8): 780-781

Brébion, G.; Amador, X.; Smith, M.J.; Malaspina, D.; Sharif, Z.; Gorman, J.M., 2000: Opposite links of positive and negative symptomatology with memory errors in schizophrenia. We wished to confirm and extend a previous correlational study of our group, suggesting that positive symptoms in schizophrenia were linked to an increase in certain types of memory errors, and negative symptoms to a decrease in other types of err...

Byrnes, D.P., 2003: Trust. Annual oration: Royal Victoria Hospital, Belfast, 3rd October 2002. Ulster Medical Journal 72(1): 43-47

Cohler B.J., 1972: Psychoanalysis adaptation and education part 1 reality and its appraisal. Psychological Reports 30(3): 695-718

Hosseinzadeh-Khanmiri, R.; Moghimi, A.; Shaabani, A.; Valizadeh, H.; Ng, S.Weng., 2016: Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones. Various 2-[5-(aryl)-1,2,4-oxadiazol-3-yl]quinazolin-4(3H)-ones have been synthesized from the reaction of diaminoglyoxime-based nitrones with methyl 2-aminobenzoate or 2-aminobenzamide in the presence of acetic acid at 100 °C. The reaction was ex...

Hupp, E.R., 1940: Suppression of spore formers in coliform isolation. Jour Bact 39(5): 631

Shariff, A.; Murphy, R.F.; Rohde, G.K., 2010: A generative model of microtubule distributions, and indirect estimation of its parameters from fluorescence microscopy images. The microtubule network plays critical roles in many cellular processes, and quantitative models of how its organization varies across cell types and conditions are required for understanding those roles and as input to cell simulations. High-thro...