+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years

, : Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years. Archives of General Psychiatry 62(7): 753-760

Context: A major criterion to validate diagnoses is stability over time.Objective: To examine the stability of several classification systems for lifetime diagnosis of alcohol dependence, to identify characteristics predicting stability of alcoholism, and to study stability of lifetime assessments of habitual smoking (1 pack per day for at least 6 months) and other drug dependence.Design: Participants in the Collaborative Study on the Genetics of Alcoholism were interviewed using the Semi-Structured Assessment for the Genetics of Alcoholism and reevaluated 5 years later. Initial and follow-up interviews were available for 1728 individuals (641 index cases, 800 siblings, 287 controls) with lifetime diagnoses of alcohol dependence, other substance dependence (marijuana, cocaine, other stimulants, sedatives, opioids), or habitual smoking at first interview. The likelihood that an individual with a lifetime history of substance dependence or habitual smoking at the first interview retained this classification after 5 years was examined to assess stability of diagnosis.Results: Stability of a lifetime diagnosis of alcohol dependence varied among the subject groups of index cases, siblings, and community-based controls. Alcohol dependence as defined by DSM-III-R criteria was highly stable in the index cases (90.5% women, 94.7% men) but much less stable in the community-based controls (27.5% women, 64.7% men). The most important characteristic associated with stability of diagnosis of alcohol dependence was severity, defined by the number of alcohol-related symptoms. Other DSM-III-R substance dependence disorders varied in the stability of diagnosis over a 5-year period. Lifetime history of habitual smoking was highly stable in all subject groups (96.0% overall).Conclusions: Stability of lifetime assessment of alcohol dependence varies depending on severity of illness. Severe cases of alcohol dependence are more likely to be stable, whereas general population cases of alcohol dependence are less likely to have stable diagnoses. The stability of diagnosis for other substance dependence varies from substance to substance.


PMID: 15997016

DOI: 10.1001/archpsyc.62.7.753

Other references

Axt-Fliedner, R.; Hendrik, H.J.; Ertan, K.; Remberger, K.; Schmidt, W., 2002: Course and outcome of a pregnancy with a giant fetal cervical teratoma diagnosed prenatally. We report the course and outcome of a pregnancy involving a giant fetal neck teratoma which was diagnosed at 23 weeks of gestation. Sonographic surveillance of the fetal neck revealed continuing growth of the tumor with development of polyhydramni...

Rajabally, Y.A., 2010: Immune therapy for chronic inflammatory demyelinating polyneuropathy: from clinical trials to real-life. European Journal of Neurology 17(2): 171-172

Miller E.R.; Miller E.C.; Green F.F.; K.P.K.; Whetter P.A.; Ullrey D.E., 1974: Studies with a swine waste re cycling system. Journal of Animal Science 39(1): 186-187

Chatterton, R.T.; Kazer, R.R.; Rebar, R.W., 1991: Depletion of luteal phase serum progesterone during constant infusion of cortisol phosphate in the cynomolgus monkey. Objective: To study the impact of chronic infusions of cortisol phosphate on ovarian function in the cynomolgus monkey. Design: Cortisol phosphate at doses of 5 or 15 mg/d of saline were infused for periods of up to 8 weeks using subcutaneously im...

Skwarek, M., 2004: Recent controversy surrounding lipid rafts. Lipid rafts (LRs) are highly enriched in glycosphingolipicts, sphingomyelins, and cholesterol membrane microdomains, existing in a liquid-ordered phase of the plasma membrane. In the literature, LRs are also known as detergent-insoluble membranes,...

Marcellin P.; Boyer N.; Giostra E.; Areias J.; Degott C.; Degos F.; Erlinger S.; Benhamou J.P., 1990: Long term follow up of patients with chronic non a non b hepatitis with complete response to recombinant interferon alfa. Hepatology 12(4 PART 2): 847

Leinfelder, K.F.; Wilder, A.D.; Teixeira, L.C., 1986: Wear rates of posterior composite resins. The wear rates of nine posterior composite resins were determined for a period of up to 3 years. The wear rates observed depended on the method used for evaluation. A quantitative method of evaluation showed that the wear rates decreased with time...

Sanchez-Lanier, M.; Guerin, P.; McLaren, L.C.; Bankhurst, A.D., 1988: Measles virus-induced suppression of lymphocyte proliferation. The mechanism by which measles virus induces immunosuppression was investigated using an in vitro system employing phytohemagglutinin (PHA)-induced human peripheral mononuclear cell (PBMC) proliferation. At a multiplicity of infection of 1.0 or gr...

G.L.ngworth; M.G.T.wnsend; R.P.ovencher; H.K.dama, 1987: Magnetic interaction in biotites and oxidised biotites. Physics and Chemistry of Minerals 15(1): 71-77

Gucinski, H.; Ziemer, M.J.; Ziemer, R.R.; Brookes, M.H., 2001: Forest roads: A synthesis of scientific information. Effects of roads in forested ecosystems span direct physical and ecological ones (such as geomorphic and hydrologic effects), indirect and landscape level ones (such as effects on aquatic habitat, terrestrial vertebrates, and biodiversity conserva...