geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD


, : Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. Journal of Bone and Mineral Research 21(9): 1464-1474

Introduction: The incidence of osteoporosis, a disease that manifests in the elderly, may be reduced by increasing peak bone mass in the young. Preliminary data indicate that extremely low-level mechanical signals are anabolic to bone tissue, and their ability to enhance bone and muscle mass in young women was investigated in this study. Materials and Methods: A 12-month trial was conducted in 48 young women (15-20 years) with low BMD and a history of at least one skeletal fracture. One half of the subjects underwent brief (10 minutes requested), daily, low-level whole body vibration (30 Hz, 0.3g); the remaining women served as controls. Quantitative CT performed at baseline and at the end of study was used to establish changes in muscle and bone, mass in the weight-bearing skeleton.Results: Using an intention-to-treat (ITT) analysis, cancellous bone in the lumbar vertebrae and cortical bone in the femoral midshaft of the experimental group increased by 2.1% (p = 0.025) and 3.4% (p < 0.001), respectively, compared with 0.1% (p = 0.74) and 1.1% (p = 0.14), in controls. Increases in cancellous and cortical bone were 2.0% (p = 0.06) and 2.3% (p = 0.04) greater, respectively, in the experimental group compared with controls. Cross-sectional area of paraspinous musculature was 4.9% greater (p = 0.002) in the experimental group versus controls. When a per protocol analysis was considered, gains in both muscle and bone were strongly correlated to a threshold in compliance, where the benefit of the mechanical intervention compared with controls was realized once,subjects used the device for at least 2 minute/day (n = 18), as reflected by a 3.9% increase in cancellous bone of the spine (p = 0.007), 2.9% increase in cortical bone of the femur (p = 0.009), and 7.2% increase in musculature of the spine (p = 0.001) compared with controls and low compliers (n = 30).Conclusions: Short bouts of extremely low-level mechanical signals, several orders of magnitude below that associated with vigorous exercise, increased bone and muscle mass in the weight-bearing skeleton of young adult females with low BMD. Should these musculoskeletal enhancements be preserved through adulthood, this intervention may prove to be a deterrent to osteoporosis in the elderly.

US$19.90

PMID: 16939405

DOI: 10.1359/jbmr.060612


Other references

Missiaen, M., 1994: Rwanda & Africas fragile food systems. Agricultural outlook (211) 15-17

Recek, C.; Mazák, J.; Cernoch, Z.; Kren, V., 1969: Angiographic evaluation of the thrombolytic effect of streptokinase. Rozhledy V Chirurgii 48(4): 172-179

Bhattacherjee, H., 1984: Syndrome with oculo dento auriculo cerebral malformation. Indian Journal of Ophthalmology 32(3): 185-186

Nappi G.; Poloni M.; Bono G.; Savoldi F., 1974: Levels of 5 hydroxy iaa in the cerebro spinal fluid of patients with migraine before and after treatment with l tryptophan. Bollettino Societa Italiana Biologia Sperimentale 50(14): 1037-1042

Ponce F.R.V.; Murad, Márcio.A.; Lima, S.A., 2013: A Two-Scale Computational Model of ip H-Sensitive Expansive Porous Media. We propose a new two-scale model to compute the swelling pressure in colloidal systems with microstructure sensitive to <i>pH</i> changes from an outer bulk fluid in thermodynamic equilibrium with the electrolyte solution in the nanopo...

Geltser, B.I.; Frisman, M.V., 2003: Principles of evidence-based medicine in drug therapy of circulatory diseases. Terapevticheskii Arkhiv 75(4): 86-90

Hubacher, M.; DeLuca, J.; Weber, P.; Steinlin, M.; Kappos, L.; Opwis, K.; Penner, I-Katharina., 2016: Cognitive rehabilitation of working memory in juvenile multiple sclerosis-effects on cognitive functioning, functional MRI and network related connectivity. To assess possible effects of working memory (WM) training on cognitive functionality, functional MRI and brain connectivity in patients with juvenile MS. Cognitive status, fMRI and inter-network connectivity were assessed in 5 cases with juvenile...

Orlent, H.; Deltenre, P.; Francque, S.; Laleman, W.; Moreno, C.; Bourgeois, S.; Colle, I.; Delwaide, J.; D.M.eght, Séphane.; Mulkay, J-Pierre.; Stärkel, P.; Reynaert, H., 2012: Update of the Belgian Association for the Study of the Liver guidelines for the treatment of chronic hepatitis C genotype 1 with protease inhibitors. Acta Gastro-Enterologica Belgica 75(2): 245-259

Osterman A.L.; Karasin A.I.; Zagnit'ko O.P.; Kaluger S.V.; Chestukhina G.G.; Fonshtein M.Yu; Yankovskii N.K.; Stepanov V.M., 1989: Cloning and comparative characteristics of genes coding two structurally distant delta endotoxins of bacillus thuringiensis var galleriae and bacillus thuringiensis var kurstaki. Representative total DNA libraries of Bac. thuringiensis var. kurstaki (strain Dipel) and galleriae (strain 11-67) have been constructed on the basis of phasmid vector .lambda.pSL5. Recombinant phasmid clones, carrying .delta.-endotoxin-coding gen...

Hsia, D.Y., 1966: The screening of hereditary metabolic defects among newborn infants. THE PRESENT COMMUNCIATION DESCRIBES THE USE OF FOUR APPROACHES TO THE DETECTION OF HEREDITARY METABOLIC DISORDERS: (1) the bacterial inhibition assay, (2) the reduction of nicotinamide adenine dinucleotide phosphate (NADP), (3) the use of paper ch...