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Low-mode docking search in iGluR homology models implicates three residues in the control of ligand selectivity

, : Low-mode docking search in iGluR homology models implicates three residues in the control of ligand selectivity. Journal of Molecular Recognition 18(2): 183-189

Homology models of the ionotropic rat kainate receptor iGluR6, based on the ligand binding domains of iGluR2, were constructed. A systematic analysis by low-mode docking searches of kainic acid in homology models of the native iGluR6 receptor, chimeric (iGluR2 and iGluR6) receptors and mutant receptors have identified three residues which influence the conformation of kainic acid in the binding core and hence the affinity for kainic acid. These residues are Leu650, Thr649 and Leu704, all located in domain 2. Leu650 has previously been implicated in the control of selectivity of iGluR2. However, this is the first report that suggests that Thr649 and Leu704 play a role in receptor selectivity. Copyright (c) 2004 John Wiley & Sons, Ltd.


PMID: 15476293

DOI: 10.1002/jmr.713

Other references

Lucas, A., 1990: Feeding and digestion in bivalve larvae. Unknown

Cross, T., 1962: Streptomyces species producing oxytetracycline. Nature 195: 832-833

Henker, B.; Whalen, C.K., 1989: Hyperactivity and attention deficits. Substantive progress has been made in our understanding of children considered hyperactive, especially in the interpersonal sphere. Evolving conceptualizations of hyperactivity and attention deficits are reviewed briefly, including changes in clin...

Apostolov, A., 1991: Copepodes harpacticoides cavernicoles de Bulgarie. 2. Deux nouveaux representants du genre Stygoelaphoidella Apostolov, 1985 du nord-ouest de la Bulgarie. Two new species of Harpactocoida: Stygoelaphoidella bulgarica n. sp. and S. elegans n. sp. discovered from cave waters of Bulgaria are described.

Jones, D.J., 1995: Conflict of interest in human research ethics. Ncbhr Communique 6(2): 5-10

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Morgan, C.L., 1920: Instinctive disposition. Scientia Bologna, 28: 269-277

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Marcucci, M.; Patane, F.; Nucci, N., 1981: Immunological aspects of prevention in dentistry. Mondo Odontostomatologico 23(6): 51-56