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Measurement of brain regional alpha-(11C)methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression

, : Measurement of brain regional alpha-(11C)methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Archives of General Psychiatry 61(6): 556-563

Context: The serotonin hypothesis of depression invokes a relative or absolute deficit of serotonin neurotransmission. Reduced synthesis of serotonin in the brain pathways mediating the expression of mood (ie, the limbic cortex) is a plausible candidate mechanism.


Other references

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Bloch, R.E.; Falk, D.M., 1994: Antitrust, competition, and health care reform. The goals of health care reform and the antitrust laws are similar: promotion of consumer welfare. Under reform, having large groups of consumers and providers will offer substantial efficiencies in purchasing and providing health care services bu...

Craddock, C.G.; Adams, W.S.; Figueroa, W.G., 1953: Interference with fibrin formation in multiple myeloma by an unusual protein found in blood and urine. A case of multiple myeloma is descr. in which an abnormality of plasma proteins was associated with impaired fibrinogen conversion. Visually, this was manifested by a total gelling of the blood or plasma without development of fibrin strands. The...

Heidari, B.; FitzPatrick, D.; Synnott, K.; McCormack, D., 2004: Modelling of annulus fibrosus imbalance as an aetiological factor in adolescent idiopathic scoliosis. Objective. To assess and model the influence of collagen fibre imbalance within the annulus fibrosus on the initiation and progression of adolescent idiopathic scoliosis deformity. Background. A number of aetiological factors have been proposed fo...

Shirokov, Y.G., 1994: Ecology-hygiene-environmental protection. The article covers hygienic and ecologic aspects of activities in environmental protection. The authors present data on environmental pollution in this country and in the world, on main polluters and changes in the present situation; show close re...

Anonymous, 1993: 1993 AAN Membership Directory. Neurology 43(1 Pt 2): 1-245

Bonin B.; Chotin P.; Giret A.; Orsini J.B., 1979: Study of the Corso-Sardinian Block by satellite imagery; the problem of differential displacement between the two islands. Revue de Geographie Physique et de Geologie Dynamique 21(2): 147-154

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Anan'ev V.G.; Kapuller L.L.; Eropkin P.V.; Shiyataya O.K., 1984: Changes in the lymphatic system following endolymphatic injection of the oil solution of dibunol. Endolymphatic infusions of a 10% solution of dibunol in iodolipol or chromolymphotrast were given for prevention of lymphogenic dissemination of rectal cancer [in humans]. Certain changes in X-ray pattern of lymphogenic metastases developed due to...

Ciolkosz, E.J.; Petersen, G.W.; Cunningham, R.L.; Matelski, R.P., 1979: Soils developed from colluvium in the ridge and valley area of Pennsylvania. Soils developed from colluvium are found on the side slopes of all the major and many of the secondary ridges in the unglaciated Ridge and Valley area of Pennsylvania. The texture of these soils varies from sandy loam to clay and, for the most par...