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Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis

, : Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis. British Journal of Clinical Pharmacology 58(4): 367-377

Aim If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information.


PMID: 15373929

DOI: 10.1111/j.1365-2125.2004.02170.x

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