+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability

, : Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Journal of Medicinal Chemistry 49(13): 3948-3954

This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay ( PAMPA). Effective permeability coefficients ( P-e) determined for a set of compounds using the PAMPA technique with isopropyl myristate ( IPM) and silicone oil, alone or in mixture, were compared to the corresponding human skin permeability coefficient values ( K-p). A good correlation between Pe and Kp was found for compounds tested through a membrane consisting of 70% silicone and 30% IPM. Moreover, positive correlation between the membrane retention of compounds and stratum corneum/water partition coefficients ( P-SC) was established. These results showed that this new artificial membrane, defined as PAMPA-skin, is able to mimic the main barrier properties of human stratum corneum and can be used for the fast prediction of passive human skin permeability coefficients.


PMID: 16789751

DOI: 10.1021/jm060230+

Other references

Grewe, F., 1967: Antracol, a new fungicide of the alkylene bisdithiocarbamic acid group. Details are given of the chemical, physical, toxicological, and biological properties of antracol . Recorded results on grapevine, hop, top fruits, field crops and vegetables, tobacco, tea, and banana are briefly outlined. Residues and safety inte...

Nishimori T.; Buzzi G.; Moskowitz M.; Uhl G.R., 1989: Nucleus caudalis preproenkephalin messenger rna biphasic enhancement by afferents. Society for Neuroscience Abstracts 15(1): 343

Sandler, N.; Salmela, I.; Fallarero, A.; Rosling, A.; Khajeheian, M.; Kolakovic, R.; Genina, N.; Nyman, J.; Vuorela, P., 2014: Towards fabrication of 3D printed medical devices to prevent biofilm formation. The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material...

Schonau, A.; Wilhelmij, H., 1980: Site. Technical communication South Africa Department of Agriculture and Fisheries: 74) 135-140

Byles, J.E.; Mishra, G.D.; Harris, M.A., 2005: The experience of insomnia among older women. Study Objectives: To measure sleeping difficulty and sleep quality among older women, explore experience and attitudes towards sleep, and test for negative association between difficulty sleeping and health-related quality of life.Design: Four-yea...

X.J.An; Wang MaoHua, 1998: Parallel processing in apple grading with machine vision. A real-time vision system including image capture, image analysis, feature extraction and classification was developed to inspect and grade apples. Orientation and detection of size, shape, colour, and defects are discussed. Parallel genetic algor...

Anonymous, 2007: A third of lecturers in east anglia face losing their jobs. NlmCategory="UNASSIGNED">Up to a third of a university's nurse lecturers face redundancy after the local strategic health authority (SHA) cut education budgets.

Yamashita, M.; Inaba, T.; Oda, Y.; Mizukawa, N.; Ushijima, Y.; Furuya, S.; Nakahashi, H., 1990: Evaluation of renal blood volume by PET--the aorta-kidney equilibrium monitored with C15O. Twenty subjects inhaled C15O and its dynamics were monitored to determine when equilibrium between the aorta and kidney occurred. One minute after inhalation, the increase in radioactivity in the aorta paralleled that in the kidney, but thereafter...

W.Yan, 1982: Tectono-volcanic depression of Lishui; types of volcanic structure and evolution model. Bulletin of the Nanjing Institute of Geology and Mineral Resources, Chinese Academy of Geological Sciences = Nan-Ching Ti Chih K'uang Ch'an Yen Chiu So So K'an 3(1): 57-77

Atta, M.; Idris, A.; Bukhari, A.; Wahidin, S., 2014: Intensity of blue LED light: a potential stimulus for biomass and lipid content in fresh water microalgae Chlorella vulgaris. Light quality and the intensity are key factors which render microalgae as a potential source of biodiesel. In this study the effects of various intensities of blue light and its photoperiods on the growth and lipid content of Chlorella vulgaris w...