geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis


, : Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis. Rhinology 42(2): 85-91

Phospholipase A2 (PLA2) is a family of enzymes that play different role(s) in inflammation, but their importance in seasonal allergic rhinitis (SAR) has not been clarified. Here, we determined the levels of messenger ribonucleic acid (mRNA) for different PLA2 types in the nasal mucosa of SAR patients (n = 6) and healthy controls (n = 5). Nasal brush samples were taken both during pollen season, when the symptoms of the patients were severe, and off-season, when the patients were free of symptoms. We found that PLA2 IB, IIA, IID, IIE, IIF, III, IVA, IVB, IVC, VIA, VIB, VIIA, VIIB, VIIIA, VIIIB, X, XII and XIII were all expressed in each subject at both occasions. The mRNA levels of PLA2 VIIA (platelet-activating factor (PAF) acetylhydrolase) were lower in SAR patients than controls, both during pollen season (p = 0.03) and off season (p = 0.03). These findings demonstrate that a large number of PLA2 types are expressed in the nasal mucosa, regardless of whether there is ongoing allergic inflammation or not. The observation that PAF acetylhydrolase mRNA expression in the nasal mucosa is lower in SAR patients than in healthy subjects suggests the possibility that impaired ability to inactivate PAF might be of importance in SAR. Further studies are required to clarify whether the decreased PAF acetylhydrolase mRNA expression in SAR is accompanied by decreased enzyme activity and whether aberrations in PAF acetylhydrolase are present in infectious rhinitis patients as well.

US$29.90

PMID: 15224635


Other references

Jellinger, K., 1990: Traumatic basal ganglia hemorrhage. Neurology 40(5): 862-863

Mcconnachie, G.; Pass, I.; Leslie, N.; Downes, C.P., 2001: Characterisation of a PTEN homologue from drosophila. Biochemical Society Transactions 29(3): A71

Hua, L.K.; Vandiver, H.S., 1949: On the Nature of the Solutions of Certain Equations in a Finite Field. Proceedings of the National Academy of Sciences of the United States of America 35(8): 481-487

Merrill, Wg, 1991: Monitor mastitis by using lactation linear scores. St Lawrence County agricultural news 75(4): 12-13

Legros, R., 1902: Contribution a l'etude de l'appareil vasculaire de l'Amphioxus. Circulation des parois du corps. R. LEGROS, Mt. Stat. Neapel xv, pp. 487-554, pls. xx-xxiii, has a contribution to tho study of tho vascular system of tho Amphioxus.

Long, Gáinne.H.; Boots, M., 2011: How can immunopathology shape the evolution of parasite virulence?. Immunopathology (immune-mediated pathology) is a ubiquitous cause of disease during infection, but how will parasite exploitation strategies evolve in its presence? Immunopathology can act to increase parasite fitness if it increases transmission...

Cha, S-Whan.; Kim, I.Yong.; Kim, Y.Wan., 2016: Quantitative measurement of elasticity of the appendix using shear wave elastography in patients with suspected acute appendicitis. Shear wave elastography (SWE) has not been studied for diagnosing appendicitis. We postulated that an inflamed appendix would become stiffer than a normal appendix. We evaluated the elastic modulus values (EMV) by SWE in healthy volunteers, patien...

Hagan, A., 1987: Controlling Entomosporium leaf spot on woody ornamentals. Circular ANR Cooperative Extension Service Auburn University: 87 (392)

Anonymous, 2000: Athlete physicians. Virtual Mentor 2(10): -

Robinson, S.; Van Os, R.; Sheridan, T.M.; Mauch, P., 1997: Hematopoietic changes in mice following administration of cyclophosphamide and G-CSF to predict engraftment. Blood 90(10 SUPPL 1 PART 1): 93A, Nov 15