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Possible mechanisms of neurodegeneration in schizophrenia


, : Possible mechanisms of neurodegeneration in schizophrenia. Neurochemical Research 31(10): 1279-1294

Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.

US$19.90

PMID: 17006758

DOI: 10.1007/s11064-006-9162-3


Other references

Spiridonov, S.E.; Bai, T.T., 1995: A Gnathostoma juvenile (Spirurida: Gnathostomatoidea) recovered from the coelomic cavity of an earthworm from Laos. A gnathostomatid juvenile was found in the coelomic cavity of an earthworm, Pheretima lunata collected near a pig farm in Thakhek, South Laos. In the general shape of the body and the disposition of the hooks on the head-bulb the juvenile nematode...

Ameh, E.A.; Sabiu, L.; Mshelbwala, P.M.; Kalba, D.U.; Obienu, E., 2005: Osteomyelitis of the ischium: unusual presentation. A 7-year-old boy presented with urinary symptoms and umbilical discharge. A perivesical abscess was drained from which Staphylococcus aureus was cultured. He responded to antibiotics. Subsequently, he developed a discharging sinus in the gluteal r...

Julio, S.M.; Heithoff, D.M.; Mahan, M.J., 2000: ssrA (tmRNA) plays a role in Salmonella enterica serovar Typhimurium pathogenesis. Escherichia coli ssrA encodes a small stable RNA molecule, tmRNA, that has many diverse functions, including tagging abnormal proteins for degradation, supporting phage growth, and modulating the activity of DNA binding proteins. Here we show that...

Wciórka, J.; Cechnicki, A., 2015: Help us save the National Programme for the Protection of Mental Health (open letter). Psychiatria Polska 49(4): 871-872

Greenberg C.I.; Strube M.J.; Myers R.A., 1980: A multi trait multi method investigation of interpersonal distance. Prior research has investigated the validty of human interpersonal distance measures with respect to only 1 trait, comfort. Previous research was expanded by measuring interpersonal distance along the trait dimensions of comfort control and privac...

Tantow, F., 1935: Das Vogelleben der Niederelbe. Altona (Naturw Ver Altona):

Zhang, X.; Huang, Z-Chao.; Lu, T-Sheng.; You, S-Jiang.; Cao, Y-Jun.; Liu, C-Feng., 2016: Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. The importance and function of serum uric acid (UA) levels in patients with cardiovascular disease or stroke are unclear. We sought to evaluate the appropriate UA levels for stroke patients and the association between endogenous UA levels and clin...

Kayser, H.; Krull-Savage, U.; Rilk-van Gessel, R., 1982: Cytochromsynthese und Hamstoffwechsel in der Insektenentwicklung. Untersuchungen am Kohlweissling, Pieris brassicae L. Verhandlungen der Deutschen Zoologischen Gesellschaft, 75: 221

Ono, M.; Takimoto, R.; Osuga, T.; Okagawa, Y.; Hirakawa, M.; Yoshida, M.; Arihara, Y.; Uemura, N.; Hayasaka, N.; Miura, S.; Matsuno, T.; Tamura, F.; Sato, Y.; Sato, T.; Iyama, S.; Miyanishi, K.; Takada, K.; Kobune, M.; Kato, J., 2016: Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin. NlmCategory="UNASSIGNED">Complete remission by induction therapy in acute myelogenous leukemia (AML) can be achieved due to improvements in supportive and optimized therapy. However, more than 20% of patients will still need to underg...

Brueckner U.B.; Herrmann H.; Schmier J.; Stenger E.; Ulmer H.E., 1971: Hemodynamic changes in tourniquet shock in the dog. Zeitschrift fuer Kreislaufforschung 60(8): 740-751