geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Potent inhibition of human telomerase by helenalin


, : Potent inhibition of human telomerase by helenalin. Cancer Letters 227(2): 169-174

Telomerase activity is repressed in normal human somatic cells, but is activated in most cancers, suggesting that telomerase may be an important target for cancer therapy. Inhibition of telomerase in cancer cells has been shown to limit the growth of human cancer cells in culture. In this study, we report that helenalin, a natural sesquiterpene lactone, is a potent and selective inhibitor for human telomerase. In vitro studies indicate that this drug can inactivate telomerase directly in a manner that is dependent on concentration and time. The inhibitory action of this drug on telomerase is selective since the presence of excessive externally added proteins did not protect the inhibition and all of the other enzymes tested in this study were not inhibited by this drug. Furthermore, we demonstrated that helenalin can inhibit the expression of hTERT and telomerase in hematopoietic cancer cells. Therefore, the anti-tumor activity of helenalin is attributed, at least in part, to the inhibition of telomerase. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

US$19.90

PMID: 16112419

DOI: 10.1016/j.canlet.2004.11.045


Other references

Becker D.J.; Hansen J.D.L.; Pimstone B.L., 1971: The effects of protein calorie mal nutrition on insulin secretion in children. South African Journal of Laboratory & Clinical Medicine 17(1):

Roling, J., 1997: The top 10 strategies for dealing with redesign or resizing. Journal of Trauma Nursing 4(1): 12-12

Slivinskiĭ, G.G.; Tsvetkova, T.V.; Mazin, V.N., 1990: The presence of a correlation between erythrocyte acetylcholinesterase activity and body mass in small rodents. Studies have been made on the activity of erythrocyte acetylcholinesterase in 18 species of wild and laboratory rodents. Significant differences in the enzymic activity unrelated to taxonomic position of rodents were revealed. Negative correlation...

Holden Roy Jay, 1934: Virginia manganese ores; Origin of Oriskany manganese ore. Virginia Journal of Science Pages 51

Nitsche, J.F.; Patil, A.S.; Langman, L.J.; Penn, H.J.; Derleth, D.; Watson, W.J.; Brost, B.C., 2016: Transplacental Passage of Acetaminophen in Term Pregnancy. NlmCategory="UNASSIGNED"><b>Objective</b> The objective of this study was to determine the maternal and fetal pharmacokinetic (PK) profiles of acetaminophen after administration of a therapeutic oral dose. <b>Study...

Melvin Richard M.; Hockman Edwin L.J.; Cibrik Jerome E.; Nelson Mark A., 1984: Interim status ground water monitoring system assessments in West Virginia. Pages 180-185 1984

Fersht A.R.; Shi J P.; Knill Jones J.; Lowe D.M.; Wilkinson A.J.; Blow D.M.; Brick P.; Carter P.; Waye M.M.Y.; Winter G., 1985: Hydrogen bonding and biological specificity analyzed by protein engineering. The role of complementary hydrogen bonding as a determinant of biological specificity was examined by protein engineering of the tyrosyl-tRNA synthetase [from Bacillus stearothermophilus]. Deletion of a side chain between enzyme and substrate to l...

Girkin, J.M.; Gu, E.; Griffin, C.; Choi, H.W.; Dawson, M.D.; McConnell, G., 2004: Use of confocal and multiphoton microscopy for the evaluation of micro-optical components and emitters. We report on the application of confocal and multiphoton microscopic techniques for the evaluation of the latest generation of micro optical components. The optical emitting characteristics of arrays of matrix addressable GaN micrometer-sized ligh...

Odaka, T.; Ofuji, S., 1966: Antinuclear factor in chronic discoid erythematosus. Hifuka Kiyo. Acta Dermatologica 61(1): 1-5

Eshraghi, A.A.; Nehme, O.; Polak, M.; He, J.; Alonso, O.F.; Dietrich, W.Dalton.; Balkany, T.J.; Van D.W.ter, T.R., 2005: Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia. During systemic hypothermia, the internal temperature of the rat cochlea correlates best with the temporalis muscle and rectal temperatures. These positive correlations will be used in future studies to assess the efficacy of mild and moderate hyp...