geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection


, : Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection. Hepatology 41(5): 1019-1028

Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing so, the virus evades host adaptive immune responses, although the mechanisms responsible in this evasion are not clear. Several groups have demonstrated weak or absent HCV-specific CD4+ T cell responses during chronic HCV infection using proliferation assays and, more recently, class II tetramers. However, the functional status of HCV-specific CD4+ T cells in resolved and persistent infection is poorly understood. Using interferon gamma (IFN-gamma) and interleukin 2 (IL-2) enzyme-linked immunospot assays, we analyzed cytokine secretion patterns in chronically infected patients and compared them with those with resolved infection. In the spontaneous resolver group, strong IL-2 secretion in relation to IFN-gamma secretion was observed. However, in the persistently infected group, a consistent and significant loss of IL-2-secreting cells, compared with IFN-gamma-secreting cells, was identified. In vitro addition of IL-2 had a substantial effect in restoring CD4+ T cell activity. In conclusion, failure of IL-2 secretion, as opposed to physical deletion or complete functional unresponsiveness, appears to be an important determinant of the status of CD4+ T cell populations in chronic HCV infection. Loss of IL-2 secretory capacity may lead to disruption of IFN-gamma and proliferative function in vivo a status that characterizes the cellular immune response in both CD4+ and CD8+ compartments in chronic disease.

US$19.90

PMID: 15841456

DOI: 10.1002/hep.20669


Other references

López-Vázquez, E.; Juan, J.A.; Vila, E.; Debón, J., 1991: Reconstruction of the anterior cruciate ligament with a Dacron prosthesis. We repaired the anterior cruciate ligament of the knee using a Dacron prosthesis in fifty-four patients. Nineteen patients had an acute injury of the anterior cruciate ligament, and thirty-five had a chronic rupture. In each patient, only one knee...

Ubukata, A., 1965: Studies on cytoplasmic granules of L-strain cells. II. Identification of acid phosphatase positive cytoplasmic granules in the living state. Medical Journal of Osaka University 16(1): 43-46

Hill, P.Sr, 2002: Renovations, additions and leaseholds. Proceedings of the North American Veterinary Conference6(16): 349-350

Hellebrekers, L.J.; Baumans, V.; Bertens, A.P.; Hartman, W., 1990: The use of T61 for the humane killing of pets and laboratory animals. Experiments were carried out to determine the onset of loss of consciousness and muscle relaxation following administration of the euthanising agent T61. Simultaneous recordings of EMG, EEG, ECG and capnogram (dogs only) were obtained in acutely i...

Wilcock, A.; Van-Delden, E., 1985: A study of the effects of repeated commercial launderings on the performance of 50. Journal of consumer studies and home economics 9(3): 275-281

Kraft, W., 1977: How effective is peroral therapy with thyroid hormones in the dog. Archiv fur tierarztliche Fortbildung: 150-151

Berssaneti, F.Tobal.; Saut, A.Maria.; Barakat, Májida.Farid.; Calarge, F.Araujo., 2016: Is there any link between accreditation programs and the models of organizational excellence?. To evaluate whether accredited health organizations perform better management practices than non-accredited ones. The study was developed in two stages: a literature review, and a study of multiple cases in 12 healthcare organizations in the state...

Sherwood, D.R.; McClay, D.R., 1997: Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation. The specifications of cell types and germ-layers that arise from the vegetal plate of the sea urchin embryo are thought to be regulated by cell-cell interactions, the molecular basis of which are unknown. The Notch intercellular signaling pathway...

Anonymous, 1987: Theatre audiences in 1987. Theatre-going in France is becoming an exclusive leisure activity, of interest to a declining group of people. In 1973, 12.1% of the French went to the theatre at least once a year. By 1981, this number had fallen to 10.3% and by 1987 to 7%. Main...

Rowe, M.L.; Raudenbush, S.W.; Goldin-Meadow, S., 2012: The pace of vocabulary growth helps predict later vocabulary skill. Children vary widely in the rate at which they acquire words--some start slow and speed up, others start fast and continue at a steady pace. Do early developmental variations of this sort help predict vocabulary skill just prior to kindergarten en...