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Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats


, : Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats. Cancer Science 95(5): 399-403

In order to clarify the susceptibility of the Hras128 rat harboring copies of the human c-Ha-ras proto-oncogene to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), Hras128 rats were intragastically treated with 100 mg/kg PhIP 8 times (females) or 80 mg/kg PhIP 10 times (males) over a 9-week period, then sacrificed at weeks 12 and 30.

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