+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure

, : Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. Journal of the American College of Cardiology 44(1): 63-67

OBJECTIVES This study aimed to investigate the prognostic importance of plasma erythropoietin (EPO) levels in chronic heart failure (CHF) patients. BACKGROUND Anemia is common and is associated with an impaired survival in patients with CHF. Erythropoietin is a hematopoietic growth factor, upregulated in anemic conditions. Little is known about the pathophysiology of anemia in CHF and the prognostic importance of plasma EPO levels in CHF patients. METHODS In 74 patients with CHF (age, 61 +/- 2 years; left ventricular ejection fraction, 0.31 +/- 0.01; peak oxygen consumption, 19.1 +/- 0.6 (mean +/- SEM)) and in 15 control patients, hemoglobin levels and plasma concentrations of EPO and brain natriuretic peptide were measured. RESULTS During a mean follow-up of 3.0 years (range, 2.3 to 5.3 years), 22 patients (30%) died. Anemia was present in 24% of the patients. Multivariate analysis showed that plasma EPO (p = 0.026) and hemoglobin levels (p = 0.005) were independent predictors of survival in this CHF population. We observed only a mild inverse correlation between the logarithm of EPO and hemoglobin levels (r2 = 0.08, p = 0.02) in CHF patients, whereas the control group showed a clear significant inverse correlation (r2 = 0.44,' p = 0.007). CONCLUSIONS Elevated plasma EPO levels are associated with an impaired prognosis independent of hemoglobin levels and other established markers of CHF severity. Furthermore, in the CHF patients, EPO levels poorly correlate with the hemoglobin levels, in contrast with the control group. Copyright 2004 by the American College of Cardiology Foundation.


PMID: 15234408

DOI: 10.1016/j.jacc.2004.03.052

Other references

Murro, D.; Jakate, S., 2015: Radiation esophagitis. The esophagus is frequently exposed to radiation during treatment of advanced stages of common cancers such as lung, breast, and esophagus. However, symptomatic radiation esophagitis requiring endoscopic and histologic evaluation occurs quite rare...

Heukelekian, H.; E.A., 1960: A review of the literature of 1959 on waste water and water pollution control. This last of 3 sections covers water pollution including such aspects as pollution surveys and investigations, environmental requirements for aquatic life, toxic materials and wastes, organic wastes, radioactive wastes, microbiology, chemistry, ox...

Bhimachar, B.S., 1967: Organization of development-orientated fisheries research in India. Proceedings of the National Institute of Sciences of India (Biol Sci): 33: 211-218

Patriarca, G.; Nucera, E.; Schiavino, D.; Romano, A.; D.R.enzo, V.; Pellegrino, S.; Fais, G., 1989: Pancuronium allergy: a case report. A case of anaphylactic shock to pancuronium bromide is described in which a type I immunological reaction occurred. A 33-yr-old male anaesthetist, with no family or personal history of allergy, collapsed soon after induction of anaesthesia. The dr...

Damron, W.; Mclaren, J.1; Menino, A.J.o, 1982: Transportation stresses and their effect on subsequent feedlot performance Feeder calves, Hawaii. Research extension series Hawaii Institute of Tropical Agriculture and Human Resources: (023) 38-43

Wang, W-l.; Bi, F-c., 1988: Study on cholinesterase of army worms, Leucania separata Walker. Entomological Knowledge, 256: 330-332

Abbas, M.A.; Afifi, A.A.; Zhang, Z.W.; Kraus, J.F., 1999: Meta-analysis of published studies of work-related carpal tunnel syndrome. The published information about work-related carpal tunnel syndrome (CTS) was surveyed to identify risk estimates and possible biases influencing the risk estimates. Seventeen studies from the English-language literature were identified and study...

De-Ferradas, B.E.R., 1977: Water mites of the arrenurus genus acari parasitengona of several lentic habitats related to the parana river. The genus Arrenurus is by far the largest genus of water mites known in the neotropics and Argentina. Three species of this genus not yet known in Argentina are mentioned; A. (Megaluracarus) fuhrmanni Walter 1912; A. (M.) spathulifer Lundblad 1936...

Dandel, M.; Hummel, M.; Loebe, M.; Weng, Y.; Müller, J.; Buz, S.; Ewert, R.; Hetzer, R., 2001: Right atrial geometry and tricuspid regurgitation after orthotopic heart transplantation: benefits of a modified biatrial surgical technique. Journal of Heart and Lung Transplantation 20(2): 246-247

Xiao, Z.S.u; Zhang, Z.B.n, 2003: How to trace seeds and fruits dispersed by frugivorous animals; a review. One of the most important obstacles to studying seed dispersal by frugivorous animals is the difficulty in tracking seed fates and estimating seed shadows. So far, many tracing techniques have been applied to study the relationships between frugiv...