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Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization

, : Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization. Journal of Pharmacology and Experimental Therapeutics 319(2): 898-906

Cardiac electrical activity is modulated by potassium currents. Pigs have been used for antiarrhythmic drug testing, but only sparse data exist regarding porcine atrial ionic electrophysiology. Here, we used electrophysiological, molecular, and pharmacological tools to characterize a prominent porcine outward K+ current (I-K,I-PO) in atrial cardiomyocytes isolated from adult pigs.


PMID: 16916995

DOI: 10.1124/jpet.106.110080

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