+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis

, : Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis. Journal of Proteome Research 5(8): 1988-1995

The synovial fluid proteome in juvenile idiopathic arthritis was investigated to isolate joint-specific biomarkers that are expressed in patients displaying recurrent joint inflammation. To identify the synovial specific proteome, matched synovial fluid and plasma samples were subjected to protein separation by 2-dimension electrophoresis (2DE). Forty-three protein spots, overexpressed in the joint, were identified. Synovial fluids from children with single-event knee joint inflammation were then compared with a group with recurrent knee disease. Nine synovial specific proteins were significantly differentially expressed in the recurrent group. Proteolytic fragments of collagen X, fibrin beta-chain, and T-cell receptor alpha-region have been identified among this protein cluster. Putative biomarkers, overexpressed in the joint and differentially expressed in children with recurrent joint inflammation, have been identified. These proteins may play a significant role determining the pathological state within the chronically inflamed joint and influence disease progression in JIA. This is the first study of the synovial proteome in children.


PMID: 16889421

DOI: 10.1021/pr060129t

Other references

Mao, J.Y.; Zhao, X.H.; Dai, H.; Gao, X.J.; Lu, L.L., 2016: Rheumatoid arthritis involving tibialis posterior tendon: study on the early diagnostic value of power Doppler ultrasonography and comparison with surgery. NlmCategory="UNASSIGNED"><b>Objective:</b> To explore the value of power Doppler ultrasonography (PDUS) in the early diagnosis of tibialis posterior tendon injury induced by rheumatoid arthritis (RA). <b>Method:</...

Pelikan, J., 1978: The house mouse, a remarkable creature.. Ziva, 262: 74-76

Salyers, A.A.; Shoemaker, N.; Cooper, A.; D'elia, J.; Shipman, J.A., 1999: Genetic methods for Bacterioides species. Smith, M C M [Editor], Sockett, R E [Editor] Methods in Microbiology; Genetic methods for diverse prokaryotes 229-249

Jefferson, M., 1959: The extensor plantar reflex. Practitioner 182(1088): 248-252

D.Meis, L., 1968: Ca++ uptake in muscle microsomes. Activation by polyamines. Journal of Biological Chemistry 243(6): 1174-1179

Kim, Y.Seok.; Roh, T.Suk.; Lee, W-Jai.; Yoo, W.Min.; Tark, K-Chul., 2009: The effect of botulinum toxin A on skin flap survival in rats. This study examines the role of botulinum toxin type A (BoTA) in preventing the collapse of the peripheral vessels in the cutaneous flap and in increasing the survival of the flap. Because BoTA cleaves the SNAP-25 protein, the release of vasoconst...

Uyeno, K., 1922: The sympathetic innervation of the skin of the toad. Journal of Physiology 56(5): 359-366

Boerckel, J.D.; Uhrig, B.A.; Willett, N.J.; Huebsch, N.; Guldberg, R.E., 2011: Mechanical regulation of vascular growth and tissue regeneration in vivo. New vascular network formation is a critical step in the wound healing process and a primary limiting factor in functional tissue regeneration. Like many tissues, neovascular networks have been shown in vitro to be highly sensitive to mechanical c...

Jialal, I., 1998: Evolving lipoprotein risk factors: lipoprotein(a) and oxidized low-density lipoprotein. Cardiovascular disease is the leading cause of morbidity and mortality in Westernized populations. Evolving lipoprotein risk factors include LDL oxidation and lipoprotein(a) (lp(a)). Several lines of evidence support a role for oxidatively modifie...

Hoagland, K.D.; Drenner, R.W.; Smith, J.; Durward.; Cross, D.R., 1993: Freshwater community responses to mixtures of agricultural pesticides: effects of atrazine and bifenthrin. The individual and combined effects of atrazine and bifenthrin on lake communities were investigated in a 2-phased mesocosm study involving eighteen 5500-litre tanks containing natural plankton assemblages and bluegills (Lepomis macrochirus). The...