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Rat brain proteome in morphine dependence


, : Rat brain proteome in morphine dependence. Neurochemistry International 49(4): 401-406

The aim of this study was to reveal potential markers associated with drug dependence, using the proteornic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem mass spectrometry, allowed for identification of eleven potential dependence markers, mainly cytoplasmic and mitochondrial enzymes, e.g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families. (c) 2006 Elsevier Ltd. All rights reserved.

US$19.90

PMID: 16581157

DOI: 10.1016/j.neuint.2006.01.024


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