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Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations


, : Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations. Acta Pharmacologica Sinica 25(12): 1712-1818

AIM: To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and their inhibitors (eglin c mutants). METHODS: The three-dimensional complex structures of furin/kexin with its inhibitors, eglin c mutants, were generated by modeller program using the newly published X-ray crystallographical structures of mouse furin and yeast kexin as templates.

US$29.90

PMID: 15569420


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