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Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations

, : Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations. Acta Pharmacologica Sinica 25(12): 1712-1818

AIM: To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and their inhibitors (eglin c mutants). METHODS: The three-dimensional complex structures of furin/kexin with its inhibitors, eglin c mutants, were generated by modeller program using the newly published X-ray crystallographical structures of mouse furin and yeast kexin as templates.


PMID: 15569420

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Davis, R.M.; Kanner, R.W., 2000: Suturing device. A suturing device includes a housing having an axial lumen therethrough, at least one needle having a tip and being attached to the housing and being capable of traversing along a non-linear path from a first position wherein each such needle is s...

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Van Camp, B.G.; Cole, J.; Peetermans, M.E., 1977: HLA antigens and homogeneous immunoglobulins. Clinical Immunology and Immunopathology 7(3): 315-318

Porschen, R.; Classen, S.; Borchard, F., 1993: Vascularization of esophageal cancers and its correlation with tumor proliferation. Proceedings of the American Association for Cancer Research Annual Meeting 34(0): 74