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Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

, : Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode. Journal of General Physiology 128(3): 373-386

CRAC ( calcium release-activated Ca2+) channels attain an extremely high selectivity for Ca2+ from the blockade of monovalent cation permeation by Ca2+ within the pore. In this study we have exploited the blockade by Ca2+ to examine the size of the CRAC channel pore, its unitary conductance for monovalent cations, and channel gating properties. The permeation of a series of methylammonium compounds under divalent cation-free conditions indicates a minimum pore diameter of 3.9 angstrom.


PMID: 16940559

DOI: 10.1085/jgp.200609588

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