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Role of caspases in male infertility


, : Role of caspases in male infertility. Human Reproduction Update 10(1): 39-51

Apoptosis is characterized by a variety of changes resulting in the recognition and phagocytosis of apoptotic cells. Caspases (cysteinyl aspartate-specific proteinases) play a central role in the regulation of apoptosis in the human seminiferous epithelium. They are expressed as inactive proenzymes and participate in a cascade triggered in response to pro-apoptotic signals. To date, 14 caspases have been implicated in the human apoptotic pathway cascade. Among these, caspase-3 is considered to be a major executioner protease. Since apoptosis is a universal suicide system in almost all cells, a close control via molecular, endocrine and physical factors establishes homeostasis of cell growth and death. The proper regulation of the caspase cascade plays an important role in sperm differentiation and testicular maturity. However, caspases have been implicated in the pathogenesis of multiple andrological pathologies such as impaired spermatogenesis, decreased sperm motility and increased levels of sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility. Future research may provide a better understanding of the regulation of caspases, which may help us to manipulate the apoptotic machinery for therapeutic benefits. In this review, we summarize the consequences of caspase activation, aiming to clarify their role in the pathogenesis of male infertility.

US$19.90

PMID: 15005463

DOI: 10.1093/humupd/dmh003


Other references

Weiler, W., 1948: Uber einen pliozanen Fischrest aus Mazedonien. Zeitschrift der Deutschen Geologischen Gesellschaft, 95 pp.210-213

Bernardes, C.P.; Menaldo, D.L.; Camacho, E.; Rosa, Jé.C.; Escalante, T.; Rucavado, A.; Lomonte, B.; Gutiérrez, Jé.M.; Sampaio, S.V., 2013: Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase. Bothrops pirajai snake venom was analyzed by a proteomic strategy. Proteins were separated by RP-HPLC, followed by SDS-PAGE, in-gel tryptic digestion, identification by MALDI-TOF/TOF mass spectrometry, and assignment to known protein families by s...

Stöllberger, C.; Bastovansky, A.; Finsterer, J., 2014: Is there a role for new oral anticoagulants as primary and secondary stroke prevention in atrial fibrillation and intracranial stenosis?. Journal of Thrombosis and Thrombolysis 36(4): 492-494

Neimark, A.V.; Coudert, Fçois-Xavier.; Triguero, C.; Boutin, A.; Fuchs, A.H.; Beurroies, I.; Denoyel, R., 2011: Structural transitions in MIL-53 (Cr): view from outside and inside. We present a unified thermodynamic description of the breathing transitions between large pore (lp) and narrow pore (np) phases of MIL-53 (Cr) observed during the adsorption of guest molecules and the mechanical compression in the process of mercu...

Benton, R.M.; Shub, J.L., 1994: Peer review in New York State. A guide. Dental Society of the State of New York, Council on Peer Review. New York State Dental Journal 60(4): 23-26

Xu, X.; Denic, A.; Jordan, L.R.; Wittenberg, N.J.; Warrington, A.E.; Wootla, B.; Papke, L.M.; Zoecklein, L.J.; Yoo, D.; Shaver, J.; Oh, S-Hyun.; Pease, L.R.; Rodriguez, M., 2016: A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neurological disease that primarily affects spinal cord anterior horn cells and their axons for which there is no treatment. Here we report the use of a recombinant natural human IgM that...

Manian, F.A.; Ponzillo, J.J., 2007: Compliance with routine use of gowns by healthcare workers (HCWs) and non-HCW visitors on entry into the rooms of patients under contact precautions. BACKGROUND. Modified contact precautions ( MCP), defined as routine donning of isolation gowns ( along with routine gloving) on entry into the rooms of patients under contact precautions, regardless of the likelihood of direct exposure to the pat...

Angelov, PA., 1974: Zwei neue Otiorrhynchus - Arten aus Bulgarien (Curculionidae, Coleoptera). Compte r Acad bulg Sci, 275: 685-687

Tözsér, József., 2010: Comparative studies on retroviral proteases: substrate specificity. Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of th...

Compans, R.W.lliam; Yao, Q., 1999: Anti-paramyxovirus screening method and vaccine. A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of inhibiting paramyxovirus-induced cell fusion. The...