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Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study


, : Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. Journal of Rheumatology 32(7): 1317-1323

Objective. Interleukin 1 (IL-1) plays a pivotal role in the pathogenesis of osteoarthritis (OA). In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease. We examined the safety of intraarticular (IA) injections of recombinant human IL-1Ra in patients with knee OA.Methods. A prospective multicenter trial was conducted using the continual reassessment method.

US$29.90

PMID: 15996071


Other references

Carey E.M.; Dils R., 1970: Fatty acid biosynthesis part 5 purification and characterization of fatty acid synthetase from lactating rabbit mammary gland. Biochimica et Biophysica Acta 210(3): 371-387

Cheema, S.S.; Kapur, S.P.; Chohan, J.S.; Jeyarajan, R., 1976: Cultural studies on Alternaria citri - The causal organism of stylar - end rot of citrus. The results are tabulated of the growth of 6 isolates on 3 solid and 2 liquid media.

Hunt, I.V., 1971: Age effects on yields of 4 grass species and their response to fertiliser nitrogen. In field trials in 1958-63, plots of cocksfoot cv. S143, timothy cv. S51, tall fescue cv. S170 and perennial ryegrass cv. S24 sown with white clover cv. Huia in 1958, '59 or '60 were harvested at monthly intervals during the growing seas...

Leydig, F., 1892: Springfrosch, Rana agilis; Ellritze, Phoxinus loevis. Zoologische Garten, XXXIII 321-326

Poethke W.; Anand Rao D.; Loescher K.D., 1968: Inst chromatographic characterization of the contents of cassia tora d seeds cassia obtusifolia d vietnam inst chromatography. Pharm Zentralh 107(8): 571-578

Renz, M.; Heim, C.; Bräunling, O.; Czichos, A.; Wieland, C.; Seelig, H.P., 1989: Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases. Clinical Chemistry 35(9): 1861-1863

Oikonomou, P.N., 1972: Penicillins (natural, semi-synthetic, broad spectrum) and their application in dentistry. Odontostomatologike Proodos 26(1): 51-57

Wang, M.; Li, J.; Liu, J.; Lin, X.; Xu, W., 2015: The comparison of platelet-rich fibrin and platelet-rich plasma in releasing of growth factors and their effects on the proliferation and differentiation of adipose tissue-derived stem cells in vitro. To compare the releasing of growth factors between platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) as well as their effects on the proliferation and differentiation of adipose tissue-derived stem cells (ADSCs) in vitro. Blood was taken f...

Kawai H.; Morishima H.; Koga T.; Nishiwaki Y., 1978: Studies on the tritium measurement in rain and ground water in japan. Annual Report of Kinki University Atomic Energy Research Institute (15): 1-20

Beitler, J.J.; Chen, A.Y.; Jacobson, K.; Owens, A.; Edwards, M.; Johnstone, P.A.S., 2010: Health literacy and health care in an inner-city, total laryngectomy population. Literacy in the head and neck cancer patient has been understudied. Health literacy (HL) is "the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate...