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Sequential genotyping within TDT families

, : Sequential genotyping within TDT families. Mathematical Medicine and Biology 21(2): 115-127

We demonstrate that, given a limited amount of genotyping resources, the power of a TDT study can be increased substantially by genotyping within families sequentially. By sequential genotyping we mean that one parent in a family should be typed and then the decision on whether to continue genotyping the family is based on this parent's genotype. If it is decided to continue genotyping then a further decision is made about whether to genotype the offspring once the second parent has been genotyped. We show that, for a given power, reductions in sample size of over 80% are possible, even for the most robust selection strategies. We discuss the practical application of such sequential genotyping and illustrate its potential using a real data set.


PMID: 15228102

DOI: 10.1093/imammb/21.2.115

Other references

Petrov, A.P., 1954: Relation of plants of the herb layer in mixed Oak woods to certain soil fertility factors.. During studies of forest types in the Tartar Republic (and, less extensively, in the Chuvash Republic) counts were made of the herbaceous flora and soil samples taken from the humus horizon (usually 3-10, in some cases 6-14 cm. ; i.e. the main roo...

Milgram, S.L.; Eipper, B.A., 1995: The biogenesis of secretory granules and the trafficking of integral membrane PAM. Journal of Cellular Biochemistry Supplement 0(19B): 236

Moor Jankowski J., 1990: Seventh symposium on nonhuman primate models for aids portland oregon usa october 1989. Journal of Medical Primatology 19(3-4): 163-437

Tomomatsu T.; Yorifuji S.; Fukuzaki H.; Sera K.; Yuwasaki T.; Mizutani T.; Sato H.; Hazeki T.; Matsuura H.; Saito Y.; Okamoto R.; Morimoto M.; Tanemoto K.; Nishida K.; Matsuo T.; Tsuchiya G.; Matsumoto S., 1972: Clinical and experimental studies on myo cardial infarction with special reference to treatment for the acute stage. Japanese Journal of Medicine 11(4): 195-196

Barczi, A.; Penksza, K.; Joo, K., 2004: Soil-plant associations on mounds found on the great Hungarian Plain. Observations were made on the vegetation and soil of 4 mounds in the Great Hungarian Plain, the sides of which were found to have different types of vegetation. However, neither the soil morphological characteristics nor the physical and chemical...

Akopyan E.V.; Zagorul'ko T.M., 1988: Differences in the sensory supply of the anterior and posterior limbic cortex of rats. Using retrograde axonal transport of horseradish peroxidase, studies have been made on the thalamic projections in the anterior and posterior parts of the limbic cortex with special reference to exterceptal system projections (visual, auditory and...

D.B.nedittis, G.; D.G.nda, F., 1985: Hemispheric specialization and the perception of pain: a task-related EEG power spectrum analysis in chronic pain patients. At EEG power spectrum analysis, chronic pain patients showed less alpha asymmetry than normal subjects during resting conditions, independently of the aetiology of pain. This 'quasi-symmetry' remained substantially unchanged across discr...

Worms, G., 1928: Multiple cranial osteogenic exostoses and atrophic rhinitis. Ann Anat Path Et Med Chir 5(4): 464-466

Grossie, V.B.; Yick, J.; Alpeter, M.; Welbourne, T.C.; Ota, D.M., 1993: Glutamine stability in biological tissues evaluated by fluorometric analysis. Although glutamine has been considered unstable during storage and therefore difficult to quantitate, recent results suggest this amino acid is stable at low pH ranges. We evaluated the stability of glutamine in plasma and tissue extracts, using f...

Vlad, G.; Stokes, M.B.; Liu, Z.; Chang, C-Chao.; Sondermeijer, H.; Vasilescu, E.R.; Colovai, A.I.; Berloco, P.; D'Agati, V.D.; Ratner, L.; Cortesini, R.; Suciu-Foca, N., 2010: Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc. Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can ef...