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Sequential genotyping within TDT families


, : Sequential genotyping within TDT families. Mathematical Medicine and Biology 21(2): 115-127

We demonstrate that, given a limited amount of genotyping resources, the power of a TDT study can be increased substantially by genotyping within families sequentially. By sequential genotyping we mean that one parent in a family should be typed and then the decision on whether to continue genotyping the family is based on this parent's genotype. If it is decided to continue genotyping then a further decision is made about whether to genotype the offspring once the second parent has been genotyped. We show that, for a given power, reductions in sample size of over 80% are possible, even for the most robust selection strategies. We discuss the practical application of such sequential genotyping and illustrate its potential using a real data set.

US$19.90

PMID: 15228102

DOI: 10.1093/imammb/21.2.115


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