geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival


, : Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Research 63(23): 8103-8107

The transcription factor activating transcription factor 2 (ATF2) has been shown to be associated with melanocytic oncogenesis and melanoma tumor proliferation in preclinical models. The clinical significance of ATF2 expression is unknown. To determine the prognostic value of ATF2 in melanoma, we evaluated the pattern and level of ATF2 expression in a large cohort of melanoma specimens. Immunohistochemical staining was performed on a tissue microarray representing 544 patients with a mean follow-up time of 60 months. Expression was evaluated semiquantitatively and correlated with overall survival and other clinicopathological data. Strong cytoplasmic ATF2 expression was associated with primary specimens rather than metastases (P < 0.0001) and with better survival (P = 0.0003). Strong nuclear ATF2 expression was associated with metastatic specimens (P < 0.0001) and with poor survival (P = 0.0008). Patients who had both weak cytoplasmic and strong nuclear ATF2 staining had the worst outcome, both among the full cohort of patients (P < 0.0001) and among the patients with localized disease (n = 269; P < 0.0001). On multivariate analysis of the primary cutaneous specimens, weak cytoplasmic staining and strong nuclear staining was an independent predictor of poor outcome, as was Clark level. Nuclear ATF2 is likely to be transcriptionally active, whereas cytoplasmic ATF2 probably represents an inactive form. These findings support other preclinical findings in which transcriptionally active ATF2 is involved in tumor progression-proliferation in melanoma. Moreover, our findings suggest that ATF2 might be a useful prognostic marker in early-stage melanoma.

US$29.90

PMID: 14678960


Other references

Blanc, Henri., 1912: Le musee zoologique de Lausanne. Bulletin de la Societe Vaudoise des Sciences Naturelles, 48 71-123

Finnegan, Dj, 1984: Transposable elements in eukaryotes. International review of cytology3(93): 281-326

Ambrosek, D.; González, L., 2007: Control of concerted two bond versus single bond dissociation in CH(3)Co(CO)(4) via an intermediate state using pump-dump laser pulses. Wavepacket propagations on ab initio multiconfigurational two-dimensional potential energy surfaces for CH(3)Co(CO)(4) indicate that after irradiation to the lowest first and second electronic excited states, concerted dissociation of CH(3) and th...

Ardito, R.; Sarteschi, P., 1956: First results on flame spectrophotometric determination of the potassium ion of blood and cerebrospinal fluid specimens taken simultaneously from neurological patients. Rivista di Patologia Nervosa E Mentale 77(2): 619-621

Brauner-Otto, S.R., 2015: Environmental Quality and Fertility: The Effects of Plant Density, Species Richness, and Plant Diversity on Fertility Limitation. NlmCategory="UNASSIGNED">The relationship between the environment and population has been of concern for centuries and climate change is making this an even more pressing area of study. In poor rural areas declining environmental cond...

Schaer, H., 1988: Propofol infusion for the maintenance of short-term anesthesia. The administration of propofol by infusion for maintenance of anesthesia has attracted much attention recently. We investigated the necessary infusion rate of propofol to maintain anesthesia for short surgical procedures without loss of the eviden...

Mulder, F.A.A.; Bouakaz, L.; Lundell, A.; Venkataramana, M.; Liljas, A.; Akke, M.; Sanyal, S., 2004: Conformation and dynamics of ribosomal stalk protein L12 in solution and on the ribosome. During translation, the ribosome and several of its constituent proteins undergo structural transitions between different functional states. Protein L12, present in four copies in prokaryotic ribosomes, forms a flexible "stalk" with key...

Anonymous, 1952: LONDON'S health in 1950. Medical World 75(18): 479-480

Lin, F-sen.; Ding, Q.; Guo, H.; Zheng, A.C., 2011: The herpes simplex virus type 1 infected cell protein 22. As one of the immediate-early (IE) proteins of herpes simplex virus type 1 (HSV-1), ICP22 is a multifunctional viral regulator that localizes in the nucleus of infected cells. It is required in experimental animal systems and some nonhuman cell li...

Coban, H.; Karacyk, Z.; Ece, O.I.yk, 2008: Oligo-Miocene igneous activities in Simav region, western Anatolia; implications for the late-syn- and extension-related post-collision magma series. Oligo-Miocene time is a critical tectonic period for western Anatolia, showing a drastic tectonic change from E-W trending compression to N-S trending extensional regime due to western movement of Anatolian Block. The rate of western movement has...