+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Subclinical carotid atherosclerosis in HIV-infected patients: role of combination antiretroviral therapy

, : Subclinical carotid atherosclerosis in HIV-infected patients: role of combination antiretroviral therapy. Stroke 37(3): 812-817

Background and Purpose-Whether or not combination antiretroviral therapy (CART) alone directly contributes to accelerating atherosclerosis in HIV-infected patients has not been studied in depth. This study aimed to ascertain the relationship between this therapy and subclinical carotid atherosclerosis according to cardiovascular risk.Methods-Sixty-eight HIV-infected patients with <= 1 cardiovascular risk factors and 64 with >= 2 risk factors completed the study protocol consisting of clinical, laboratory, and vascular evaluation by carotid high-resolution B-mode ultrasonography. Univariate and multivariate logistic regression analyses were performed with the presence of subclinical carotid atherosclerosis, defined by carotid intima-media thickness > 0.8 mm or the presence of plaque being the dependent variable.Results-Among the 132 enrolled patients, 93 (70.5%) were on CART and 39 (29.5%) had never been on antiretroviral therapy. In accordance with cardiovascular risk stratification, subclinical carotid atherosclerosis was found in 26.6% (17 of 64 patients) of the very low-risk group (10-year coronary risk < 5%), 35.3% ( 12 of 34 patients) of the low-risk group (10-year coronary risk between 5% and 9%) and 76.5% ( 26 of 34 patients) of the moderate/high-risk group (10-year coronary risk >= 10%). Thus, 55 (41.7%) of the 132 HIV-infected patients had subclinical carotid atherosclerosis, and independent variables associated with carotid atherosclerosis (odds ratio; 95% CI) were: CART exposure (10.5; 2.8 to 39) and 10-year coronary risk >= 10% (4.2; 1.5 to 12). In very low coronary risk patients (< 5%), age (per 10-year increment: 4.01; 1.12 to 14.38), systolic blood pressure (per unit mm Hg 1.07; 1.01 to 1.14), and CART exposure (8.65; 1.54 to 48.54) were independently associated with subclinical carotid atherosclerosis.Conclusions-CART should be considered a strong, independent predictor for the development of subclinical atherosclerosis in HIV-infected patients, regardless of known major cardiovascular risk factors and atherogenic metabolic abnormalities induced by this therapy.


PMID: 16439699

DOI: 10.1161/01.STR.0000204037.26797.7f

Other references

Rorabaugh, B.R.; Scofield, M.A.; Smith, D.D.; Jeffries, W.B.; Abel, P.W., 2001: Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. Calcitonin gene-related peptide (CGRP) receptors are classified into CGRP subtype 1 (CGRP(1)) and CGRP subtype 2 (CGRP(2)) based on the affinity of the antagonist, human alpha (halpha)-CGRP(8-37). halpha-CGRP(8-37) antagonizes CGRP(1) receptor-med...

Bernabeu, E.; Gonzalez, L.; Legaspi, M.J.; Moretton, M.A.; Chiappetta, D.A., 2016: Paclitaxel-Loaded TPGS-b-PCL Nanoparticles: In Vitro Cytotoxicity and Cellular Uptake in MCF-7 and MDA-MB-231 Cells versus mPEG-b-PCL Nanoparticles and Abraxane®. Nanomedicines have become an attractive platform for the development of novel drug delivery systems in cancer chemotherapy. Polymeric nanoparticles (NPs) represent one of the best well-investigated nanosized carriers for delivery of antineoplastic...

Mohammed, S.I.; Meloni, G.B.; Pinna Parpaglia, M.L.; Marras, V.; Burrai, G.P.; Meloni, F.; Pirino, S.; Antuofermo, E., 2012: Mammography and ultrasound imaging of preinvasive and invasive canine spontaneous mammary cancer and their similarities to human breast cancer. Understanding the evolution of proliferative breast disease such as atypical hyperplasia and carcinoma in situ is essential for clinical management of women diagnosed with these lesions. Therefore, an animal model that faithfully represents human...

Davis, S.F., 1974: Runway performance as a function of pellet habituation. Twenty-four patients with peptic oesophagitis or ulceration of the stomach or duodenum have been treated with irradiation of the stomach. They were selected on the grounds of their unsuitability for surgery because of associated medical conditions...

Scott, P.M.; Lau, B.P.; Lawrence, G.A.; Lewis, D.A., 2000: Analysis of Ginkgo biloba for the presence of ginkgotoxin and ginkgotoxin 5'-glucoside. Hot water extracts of Ginkgo biloba seeds were analyzed for the presence of ginkgotoxin (4'-O-methylpyridoxine) by reversed-phase liquid chromatography (LC) using methanol-0.05M KH2PO4 (1 + 9, v/v) adjusted to pH 3 as mobile phase. Detection...

Brown, S.C.; Mueller, L.; Jeffs, P.W., 1989: 1H NMR assignment and secondary structural elements of human transforming growth factor alpha. The 1H NMR spectrum of human transforming growth factor alpha (hTGF-alpha) has been completely assigned, and secondary structural elements have been identified as a preliminary step in determining the structure of this protein by distance geometry...

Konstantinides, F.N., 1992: Nitrogen balance studies in clinical nutrition. Nutrition support is recognized as an important cofactor in altering morbidity and mortality of hospitalized patients. Paramount in delivering proper nutrition support is the accurate determination of baseline metabolic and nutritional status, thu...

Mimina, V.I., 1973: Results of clinical study of the state of fillings from various filling materials. Stomatologiia 52(1): 16-20

Riera, G.S.; Naressi, M.; Velasquez, G.; Ramos, J.; Herrera, B., 2002: Randomized doubled blind twelve months study of 1 mug/day of alphacalcidiol vs placebo in a high bone turnover postmenopausal women. Journal of Bone & Mineral Research 17(Suppl 1): S276-S277, September

Domok, I.; Molnar, E., 1960: An outbreak of meningoencephalomyocarditis among newborn infants during the epidemic of Bornholm disease of 1958 in Hungary. II. Aetiological findings. Coxsackie virus type B3 was the etiological agent causing an outbreak of meningoencephalomyocarditis during an epidemic of Bornholnvs disease.