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Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa

, : Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. Journal of Immunology 177(9): 5968-5979

The human gastrointestinal mucosa is exposed to a diverse normal microflora and dietary Ags and is a common site of entry for pathogens. The mucosal immune system must respond to these diverse signals with either the initiation of immunity or tolerance. APCs are important accessory cells that modulate T cell responses which initiate and maintain adaptive immunity.


PMID: 17056521

DOI: 10.4049/jimmunol.177.9.5968

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