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Surface modification of gold and quantum dot nanoparticles with chitosan for bioapplications


, : Surface modification of gold and quantum dot nanoparticles with chitosan for bioapplications. Journal of Biomedical Materials Research. Part A 75(1): 56-62

Gold (Au) and quantum dot (QD) nanoparticles, which have been extensively used in many fields, were encapsulated with a natural polymer, chitosan, to improve their biocompatibility. Characterization was performed using ultraviolet-visible, dynamic light scattering, atomic force microscopy, and transmission electron microscope analyses. It was found that a Au/chitosan ratio of 1:1 and smaller produced chitosan-encapsulated Au nanoparticles of a sufficiently small size, and this result was then applied in the chitosan encapsulation of QDs. The biocompatibility of both types of nanoparticles was assessed in cell culture studies using HT29 human colon carcinoma and NIH 3T3 mouse fibroblast cells. MTT and trypan blue exclusion assays revealed that both chitosan-encapsulated Au nanoparticles and QDs exhibited improved biocompatibility over their bare, nonencapsulated counterparts. Therefore, this study showed that chitosan could be used to encapsulate both Au nanoparticles; and QDs in order to enhance their biocompatibility. The approaches developed in this study can also be extended to other nanoparticles for bioapplications as well. (c) 2005 Wiley Periodicals, Inc.

US$19.90

PMID: 16086419

DOI: 10.1002/jbm.a.30410


Other references

Hayes, P.L.; Lytle, B.L.; Volkman, B.F.; Peterson, F.C., 2008: The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. Here, we report the solution structure of ZNF593, a protein identified in a functional study as a negative modulator of the DNA-binding activity of the Oct-2 transcription factor. ZNF593 contains a classic C(2)H(2) zinc finger domain flanked by ab...

Rajagopal, V.; Gurm, H.S.; Bhatt, D.L.; Lincoff, A.Michael.; Tcheng, J.E.; Kereiakes, D.J.; Kleiman, N.S.; Jia, G.; Topol, E.J., 2004: Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality. Increased inflammatory markers are associated with a poor prognosis after percutaneous coronary intervention. Leukocytes play a key role in inflammation, and an increase in white blood cell (WBC) counts is a nonspecific marker of inflammation. In...

Lee, T., 2000: Regulation as a tool for improving the management of water supply and sanitation companies. The establishment of a strong independent regulator appears to be the most successful means to remedy the endemic poor management of water supply and sanitation services. This paper discusses why this is so and illustrates the argument with refere...

Kamoni, P.; Gicheru, P.; Wokabi, S.; Easter, M.M.lne, E.C.leman, K.F.lloon, P.P.ustian, K., 2007: Predicted soil organic carbon stocks and changes in Kenya between 1990 and 2030. Under the United Nations Framework Convention on Climate Change (UNFCCC), Non-Annex 1 countries such as Kenya are obliged to report green house gas (GHG) emissions from all sources where possible, including those from soils as a result of changes...

Anonymous, 2011: Society of Nematologists 2011 Meeting: Abstracts: Alphabetically by first author. Journal of Nematology 43(3-4): 223-297

Bella, P.Della.; Maccabelli, G., 2013: Temporary percutaneous left ventricular support for ablation of untolerated ventricular tachycardias: is it worth the trouble?. Circulation. Arrhythmia and Electrophysiology 5(6): 1056-1058

Lau, Y.L.; Hey, E., 1991: Sensitivity and specificity of daily tracheal aspirate cultures in predicting organisms causing bacteremia in ventilated neonates. The sensitivity of daily tracheal aspirates in predicting neonatal bacteremia was ascertained from 48 of 354 ventilated neonates who became septic during a 4-year period. Fourteen babies (designated Group A) had a positive blood culture on the fir...

Beck, G.E., 1957: Basedow disease and chronic polyarthritis. Revue Medicale de la Suisse Romande 77(1): 39-45

Onarir, R.; Kazancigil, A., 1966: Apropos of a case of virilizing thecoma. Tip Fakultesi Mecmuasi 29(3): 493-503

Lesný, I.; Stehlík, A.; Tománková, A., 1987: Observations on cases of sudanophilic leukodystrophy in a pediatric rehabilitation institution. Ceskoslovenska Neurologie A Neurochirurgie 50(1): 51-54