geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development


, : Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. Journal of Neuroscience 24(40): 8885-8895

Switching of the NMDA receptor 2A (NR2A) and NR2B subunits at NMDA receptors is thought to underlie the functional changes that occur in NMDA receptor properties during the developmental epoch when neural plasticity is most pronounced. The cellular expression of NR2A and NR2B and the NR2 synaptic binding protein postsynaptic density-95 (PSD-95) was examined in the mouse somatosensory cortex and thalamus from postnatal day 2 (P2) to P15 using reverse transcription-PCR, in situ hybridization histochemistry, and immunocytochemistry. The localization of NR2A and NR2B subunits and PSD-95 was then studied at synapses in layer IV of somatosensory cortex and in the ventral posterior nucleus of the thalamus using high-resolution immunoelectron microscopy. At both cortical and thalamic synapses, a quantitative switch in the dominant synaptic subunit from NR2B to NR2A was accompanied by a similar change in the cellular expression of NR2A but not of NR2B. Synaptic PSD-95 developed independently, although both NR2A and NR2B colocalized with PSD-95. Displacement of NR2B subunits from synapses was not accompanied by an increase in an extrasynaptic pool of this subunit. Thus, the switch in synaptic NR2 subunit predominance does not occur by changes in expression or displacement from synapses and may reflect the formation of new synapses from which NR2B is lacking.

US$19.90

PMID: 15470155

DOI: 10.1523/JNEUROSCI.2476-04.2004


Other references

Ievtukhov, M.; Berezhnyi, V., 1981: Substantiation of optimum dates. Visnyk sil's'kohospodars'koi nauki: (10) 59-61

Cross, J.; Berrie, A., 2006: The challenges of developing IPM programmes for soft fruit crops that eliminate reportable pesticide residues. Soft fruit crops are highly susceptible to a wide range of damaging pests and diseases. Thus, adequate yields of fruit of acceptable quality cannot be produced and the crops cannot be grown profitably unless these pests and diseases are efficientl...

Watase M.; Nishinari K., 1981: The effect of alkali metal ions on the rheological properties of kappa carrageenan and agarose gels. Biorheology 18(1): 147

Taylor, N.L.; Stroube, W.H.; Kendall, W.A.; Fergus, E.N., 1962: Variation and relation of clonal persistence and seed production in red clover. Plants of red clover (Trifolium pratense) clones were established in a field nursery to determine the variation in seed production and length of life span and to elucidate some of the factors involved in seed yield and persistence. Absence of viru...

Gutierrez-Campos, R.T.rres-Acosta, J.; Perez-Martinez, J.D.-J.G.mez-Lim, M., 2001: Pleiotropic effects in transgenic tobacco plants expressing the oryzacystatin I gene. A study was undertaken to evaluate possible phenotypic alterations in transgenic tobacco (Nicotiana tabacum L. cv. Xanthi) plants expressing the oryzacystatin I gene. Morphophysiologic parameters, such as growth rate, biomass, and leaf, flower, an...

Malik A.B., 1983: Lung vascular injury after thrombin induced pulmonary micro embolism role of intra vascular coagulation and fibrinolysis. Thrombosis & Haemostasis 50(1): 332

Almeida, H. de O.; Teixeira, V. de P.A.; Oliveira, A.C.F. de, 1981: Adrenal gland phlebitis caused by a parasite nest in chronic Chagas' disease patients. Analysis of autopsy material revealed chronic phlebitis of the central veins of the adrenal glands in 29 of 35 Chagas' disease patients; in 9 cases nests of Trypanosoma cruzi amastigotes were also present. Neither granulomas nor mastocytosis...

Wiernik, P.H.; Ashwin, M.; Hu, X.P.ng; Paietta, E.; Brown, K., 2001: Anticipation in familial chronic lymphocytic leukaemia. Anticipation, a phenomenon in which an inherited disease is diagnosed at an earlier age in each successive generation of a family, has been demonstrated in certain heritable neurological disorders and in multiple myeloma, non-Hodgkin's lympho...

Basama, F.M.S.; Ghani, R., 2006: A rapidly growing uterine leiomyoma and postmyomectomy ureteric fistula. Malignant transformation and particularly malignant mixed mullerian tumor arising in extragenital endometriosis is extremely rare and occurs in the majority of cases after estrogen replacement therapy. We present a case of a 75-year-old woman who...

Hou, Y.; Kondoh, H.; Shimojo, M.; Sako, E.O.; Ozaki, N.; Kogure, T.; Ohta, T., 2006: Inorganic nanocrystal self-assembly via the inclusion interaction of beta-cyclodextrins: toward 3D spherical magnetite. Synthesis and three-dimensional (3D) assembly of magnetite nanocrystals were realized by a one-pot procedure, in which Fe(acac)3 (acac = acetylacetonate) was partly reduced by hydrazine accompanied with ethylene glycol and spontaneously assembled...