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Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells


, : Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells. FEBS Letters 579(1): 265-270

Rana catesbeiana ribonuclease (RC-RNase) possesses tumor-specific cytotoxicity, which can be synergized by IFN-gamma. However, it is unclear how RC-RNase and RGRNase/IFN-gamma induce cell death. In this study, we use substrate cleavage assays to systematically investigate RGRNase- and RC-RNase/IFN-gamma-induced caspase activation in HL-60, NMCF-7, and SKHep-1 cells.

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