geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Syntheses of photolabile novobiocin analogues


, : Syntheses of photolabile novobiocin analogues. Bioorganic & Medicinal Chemistry Letters 14(23): 5903-5906

Novobiocin was recently shown to inhibit Hsp90 through a previously unrecognized C-terminal ATP binding site. Although the N-terminal region of Hsp90 has been solved by X-ray crystallography, the C-terminal region has not. In an effort to elucidate the C-terminal binding site of Hsp90, four photolabile analogues of novobiocin were prepared. Copyright 2004 Elsevier Ltd. All rights reserved.

US$19.90

PMID: 15501066

DOI: 10.1016/j.bmcl.2004.09.017


Other references

Shumakov, V.I., 1962: Modification of the artificial blood circulation apparatus of the Crawford-Senning system. Grudnaia Khirurgiia 4: 89-92

Anderson Don L., 1984: Surface wave tomography. Eos, Transactions, American Geophysical Union 65(16): 147-148

Kellogg J.A.; Seiple J.W., 1991: Comparison of swab with cytobrush for recovery of endocervical cells and for chlamydiazyme detection of chlamydia trachomatis. Abstracts of the General Meeting of the American Society for Microbiology 91: 383

Yanbe, T., 1993: Studies on pine defoliation by Dendrolimus spectabilis (Butler) and estimation of the larval density in Tohoku district. An analysis of Dendroctonus spectabilis outbreaks in Japan (in Pinus densiflora and P. thunbergii forests), and the effects of pest infestation on the extent and severity of defoliation.

Feldbush, M.W.; Mitchell, J.T., 2010: A time for renewal: a lessons-learned review on the role of CISM in caring for missionaries after the Rwandan genocide. In 1994 more than 800,000 people were killed in the Rwandan genocide. Seventh Day Adventist missionaries were forced to evacuate the country under conditions of extraordinary stress and personal threat. Their Church was faced with the necessity of...

Krumholz, Louis A., 1962: Radionuclides in the freshwater environment. U S Atomic Energy Comm Res And Develop Rept632(bk. 2): 360-371

Bhandari B.; Beckwith K.D.; Mcevoy L.T.; Miller R.E., 1988: Hormonal regulation and nucleotide sequence of the glutamine synthetase gene in cultured 3t3 l1 adipocytes. FASEB Journal 2(6): ABSTRACT 8646

Lee, B.S.; Hwang, J-Hyeok.; Lee, S.H.; Jang, S.E.; Ahn, D-Won.; Hwang, D.W.; Cho, J.Y.; Yoon, Y-Seok.; Han, H-Seong.; Ahn, S., 2013: Older adults with biliary tract cancer: treatment and prognosis. To compare survival in older (?65) and younger (<65) individuals with biliary tract cancer (BTC) and to determine whether treatment efficacy varies according to age. Retrospective cohort study and nested case control study. Tertiary referral ce...

Wagner, B.A.; Witmer, J.R.; van 't Erve, T.Joost.; Buettner, G.R., 2013: An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells. Cells have a wide range of capacities to remove extracellular hydrogen peroxide. At higher concentrations of extracellular H<sub>2</sub>O<sub>2</sub> (micromolar) the rate of removal can be approximated by a rate equation t...

Barchiesi, F.; Tortorano, A.M.; D.F.ancesco, L.Falconi.; Rigoni, A.; Giacometti, A.; Spreghini, E.; Scalise, G.; Viviani, M.A., 2005: Genotypic variation and antifungal susceptibilities of Candida pelliculosa clinical isolates. At the Istituto Ricovero Cura Carattere Scientifico, Ospedale Maggiore di Milano, Italy, Candida pelliculosa accounted for 3.3 and 4.4% of all Candida species other than Candida albicans collected during 1996 and 1998, respectively. Genetic variab...