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Syntheses of photolabile novobiocin analogues

, : Syntheses of photolabile novobiocin analogues. Bioorganic & Medicinal Chemistry Letters 14(23): 5903-5906

Novobiocin was recently shown to inhibit Hsp90 through a previously unrecognized C-terminal ATP binding site. Although the N-terminal region of Hsp90 has been solved by X-ray crystallography, the C-terminal region has not. In an effort to elucidate the C-terminal binding site of Hsp90, four photolabile analogues of novobiocin were prepared. Copyright 2004 Elsevier Ltd. All rights reserved.


PMID: 15501066

DOI: 10.1016/j.bmcl.2004.09.017

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