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Synthesis of spermidinylcholestanol and spermidinylcholesterol, squalamine analogues

, : Synthesis of spermidinylcholestanol and spermidinylcholesterol, squalamine analogues. Tetrahedron 60(50): 11477-11486

Several novel squalamine-related polyaminosterols are reported. The synthesis of 7alpha-N-(3N-(4-aminobutyl)aminopropyl)aminocholestanol I, 6alpha-N-(3N-(4-aminobutyl)aminopropyl)aminocholestanol II, 7alpha and 7beta-N-(3N-(4-aminobutyl)aminopropyl)aminocholesterol (III and IV), was accomplished from cholesterol, they provide the first examples in which spermidine is introduced in the B steroidal ring.


DOI: 10.1016/j.tet.2004.09.055

Other references

Rorabeck, C.H.; Castle, G.S.; Hardie, R.; Logan, J., 1981: Compartmental pressure measurements: an experimental investigation using the slit catheter. A new catheter employing a different technique to monitor compartmental pressure has been developed. The accuracy of the catheter was compared to a wick catheter and to the needle manometer technique for monitoring compartmental pressure. The slit...

Ruoslahti E., 1975: Role of alpha 1 feto protein as a marker in fetal distress. Hafez, E (ed.). The Mammalian Fetus. Comparative Biology And Methodology. Symposium. Detroit, Mich., U.s.a., Dec. 3-4, . Xiv 352p. Illus. Charles C Thomas, Publisher: Springfield, Ill., U.s.a. Isbn 0-398-03285-8. 236-247

D.G.speri, R.; Gama Sosa, M.A.; Naumowicz, Z.; Hof, P.R.; Notterpek, L.; Davis, K.L.; Buxbaum, J.D.; Elder, G.A., 2011: Peripheral Myelin Protein-22 Is Expressed In Cns Myelin. Myelin abnormalities exist in schizophrenia leading to the hypothesis that oligodendrocyte dysfunction plays a role in the pathophysiology of the disease. The expression of the mRNA for the peripheral myelin protein-22 (PMP-22) is decreased in sch...

Kim, Y.; You, Y.J.; Ahn, B.Z., 2002: Naphthazarin derivatives (VIII): Synthesis, inhibitory effect on DNA topoisomerase-I, and antiproliferative activity of 6-(1-acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinones. 6-(1-Acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ; 5,8-dimethoxy-1,4-naphthoquinone) derivatives were synthesized and examined for their inhibitory effect on DNA topoisomerase-I (Topo I) and their antiproliferative activity against L1210 c...

Shen, Y-Jia.; Jiang, H.; Jin, J-Peng.; Zhang, Z-Bao.; Xi, B.; He, Y-Yu.; Wang, G.; Wang, C.; Qian, L.; Li, X.; Yu, Q-Bo.; Liu, H-Juan.; Chen, D-Hui.; Gao, J-Hua.; Huang, H.; Shi, T-Liu.; Yang, Z-Nan., 2004: Development of genome-wide DNA polymorphism database for map-based cloning of rice genes. DNA polymorphism is the basis to develop molecular markers that are widely used in genetic mapping today. A genome-wide rice (Oryza sativa) DNA polymorphism database has been constructed in this work using the genomes of Nipponbare, a cultivar of...

Godt, H.; Lehmann, J., 1975: Histochemical localization of enzymes in ground sections of deciduous dentin. Zahnarztliche Praxis 26(11): 248-250

Litvak, E.; Long, M.C.; Cooper, A.B.; McManus, M.L., 2001: Emergency department diversion: causes and solutions. Academic Emergency Medicine 8(11): 1108-1110

Kirk, E.P.; Donnelly, J.E.; Jacobsen, D.J., 2001: Changes in aerobic capacity in response to long-term exercise in overweight women who gain weight. Medicine & Science in Sports & Exercise 33(5 Supplement): S337, May

Lincoff, A.Michael.; Kleiman, N.S.; Kereiakes, D.J.; Feit, F.; Bittl, J.A.; Jackman, J.Daniel.; Sarembock, I.J.; Cohen, D.J.; Spriggs, D.; Ebrahimi, R.; Keren, G.; Carr, J.; Cohen, E.A.; Betriu, A.; Desmet, W.; Rutsch, W.; Wilcox, R.G.; de Feyter, P.J.; Vahanian, A.; Topol, E.J., 2004: Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial. Context In the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial, bivalirudin with provisional glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibition was found to be noninferior to heparin plus planned Gp IIb/IIIa...

Santa T., 1972: Effects of long term anti cholin esterase treatment on neuro muscular transmission and on motor end plate fine structure. Neurology: 401