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Synthesis of spermidinylcholestanol and spermidinylcholesterol, squalamine analogues


, : Synthesis of spermidinylcholestanol and spermidinylcholesterol, squalamine analogues. Tetrahedron 60(50): 11477-11486

Several novel squalamine-related polyaminosterols are reported. The synthesis of 7alpha-N-(3N-(4-aminobutyl)aminopropyl)aminocholestanol I, 6alpha-N-(3N-(4-aminobutyl)aminopropyl)aminocholestanol II, 7alpha and 7beta-N-(3N-(4-aminobutyl)aminopropyl)aminocholesterol (III and IV), was accomplished from cholesterol, they provide the first examples in which spermidine is introduced in the B steroidal ring.

US$19.90

DOI: 10.1016/j.tet.2004.09.055


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