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Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy

, : Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Research 66(19): 9617-9624

The lymphotoxin-beta receptor (LT beta R) is a tumor necrosis factor receptor family member critical for the development and maintenance of various lymphoid microenvironments. Herein, we show that agonistic anti-LT beta R monoclonal antibody (mAb) CBE11 inhibited tumor growth in xenograft models and potentiated tumor responses to chemotherapeutic agents.


PMID: 17018619

DOI: 10.1158/0008-5472.CAN-06-0217

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